Nerfid
Generic Name
Nerfid 150 mg capsule
Manufacturer
PharmaLife Laboratories
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nerfid 150 mg capsule | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Nerfid 150 mg capsule is used to treat neuropathic pain, which is pain caused by nerve damage. It helps to reduce nerve pain by affecting calcium channels in the central nervous system.
Uses & Indications
Dosage
Adults
Initial dose 150 mg daily, divided into 2 or 3 doses. May be increased to 300 mg daily within 1 week, based on response and tolerability, up to a maximum of 600 mg daily.
Elderly
May require lower initial doses and slower titration due to potential for reduced renal function and increased sensitivity.
Renal_impairment
Dosage adjustment necessary; consult product leaflet or physician for specific guidelines based on creatinine clearance.
How to Take
Take orally with or without food. Swallow the capsule whole with water. Do not chew, crush, or open the capsule.
Mechanism of Action
Nerfid is thought to exert its analgesic and anxiolytic effects by binding to the alpha-2-delta subunit of voltage-dependent calcium channels in the central nervous system, thereby modulating the release of several excitatory neurotransmitters.
Pharmacokinetics
Onset
Pain relief usually starts within 1-2 weeks of consistent use.
Excretion
Excreted almost entirely by the kidneys as unchanged drug.
Half life
Approximately 6-8 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached within 1 hour.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Nerfid or any component of the formulation.
- Severe kidney disease without appropriate dose adjustment.
Drug Interactions
Opioids (e.g., Morphine, Oxycodone)
May increase the risk of respiratory depression and sedation. Monitor for signs of central nervous system depression.
Central Nervous System (CNS) depressants (e.g., Benzodiazepines, Alcohol)
Increased risk of drowsiness, dizziness, and sedation. Avoid concomitant use or use with caution.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, confusion, agitation, and coma. Treatment is primarily supportive; hemodialysis may be considered in severe cases. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk; advise caution or consider alternative feeding methods during lactation.
Side Effects
Contraindications
- Hypersensitivity to Nerfid or any component of the formulation.
- Severe kidney disease without appropriate dose adjustment.
Drug Interactions
Opioids (e.g., Morphine, Oxycodone)
May increase the risk of respiratory depression and sedation. Monitor for signs of central nervous system depression.
Central Nervous System (CNS) depressants (e.g., Benzodiazepines, Alcohol)
Increased risk of drowsiness, dizziness, and sedation. Avoid concomitant use or use with caution.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, confusion, agitation, and coma. Treatment is primarily supportive; hemodialysis may be considered in severe cases. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk; advise caution or consider alternative feeding methods during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired
Clinical Trials
Extensive clinical trials have demonstrated Nerfid's efficacy and safety in treating neuropathic pain and as an adjunctive therapy for partial-onset seizures.
Lab Monitoring
- Renal function (creatinine clearance) in patients with kidney impairment.
- Periodic monitoring for mood changes or suicidal ideation.
Doctor Notes
- Advise patients about potential CNS depressant effects and to avoid sudden discontinuation.
- Monitor renal function, especially in elderly or renally impaired patients, and adjust dose accordingly.
Patient Guidelines
- Do not stop taking Nerfid abruptly, as this may lead to withdrawal symptoms.
- Take the medication exactly as prescribed by your doctor.
- Avoid driving or operating heavy machinery until you know how this medication affects you.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness, drowsiness, and blurred vision. Patients should be cautioned against operating hazardous machinery or driving until they are reasonably certain that Nerfid does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Maintain a healthy diet and regular exercise to support overall well-being.
- Manage stress effectively to help reduce neuropathic pain symptoms.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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