Nerfid
Generic Name
Pregabalin
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nerfid 75 mg capsule | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Nerfid 75 mg Capsule contains Pregabalin, an anticonvulsant and neuropathic pain medication. It is used to treat neuropathic pain, fibromyalgia, and as an adjunctive therapy for partial seizures in adults.
Uses & Indications
Dosage
Adults
Initial dose 75 mg twice daily, may be increased to 150 mg twice daily within 1 week based on response and tolerability, up to a maximum of 300 mg twice daily. For certain conditions, total daily dose may range from 150 mg to 600 mg.
Elderly
May require dose adjustment due to age-related decrease in renal function. Start with a lower dose.
Renal_impairment
Requires significant dose reduction. Consult product information or physician for specific guidelines based on creatinine clearance.
How to Take
Take orally with or without food. Swallow the capsule whole with water. Do not chew, crush, or open the capsule.
Mechanism of Action
Pregabalin binds with high affinity to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding modulates calcium influx into nerve terminals, thereby reducing the release of several neurotransmitters, including glutamate, norepinephrine, and substance P. This action is thought to contribute to its anticonvulsant and analgesic effects.
Pharmacokinetics
Onset
Pain relief typically begins within 1 week for neuropathic pain.
Excretion
Primarily excreted unchanged in the urine (approximately 98% of the dose).
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 1 hour.
Metabolism
Negligible metabolism in humans; less than 0.1% of the dose is metabolized.
Side Effects
Contraindications
- Hypersensitivity to Pregabalin or any component of the formulation
Drug Interactions
Ethanol (Alcohol)
Increased impairment of motor skills and cognition.
Opioids (e.g., Oxycodone)
May enhance CNS depressant effects, leading to increased sedation and respiratory depression.
Benzodiazepines (e.g., Lorazepam)
Increased risk of sedation and somnolence.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, confusion, agitation, and coma. Treatment is supportive and symptomatic; hemodialysis may be beneficial in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to Pregabalin or any component of the formulation
Drug Interactions
Ethanol (Alcohol)
Increased impairment of motor skills and cognition.
Opioids (e.g., Oxycodone)
May enhance CNS depressant effects, leading to increased sedation and respiratory depression.
Benzodiazepines (e.g., Lorazepam)
Increased risk of sedation and somnolence.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, confusion, agitation, and coma. Treatment is supportive and symptomatic; hemodialysis may be beneficial in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, check product packaging for exact date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic versions available, original patent expired
Clinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy in neuropathic pain, fibromyalgia, and epilepsy. Trials focused on safety, tolerability, and dose-response.
Lab Monitoring
- No routine lab monitoring typically required, but renal function should be assessed before and during treatment, especially in elderly patients.
Doctor Notes
- Counsel patients on potential for dizziness and somnolence, especially at treatment initiation.
- Advise patients not to abruptly discontinue treatment.
- Monitor for signs of suicidal ideation or behavior.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor, as it may lead to withdrawal symptoms.
- Avoid alcohol while taking this medicine.
- Be cautious when driving or operating machinery until you know how this medicine affects you.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness, somnolence, and blurred vision. Do not drive or operate heavy machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Manage stress effectively.
- Inform your doctor about all other medications you are taking.
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Global Brand Names
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