Nerfid
Generic Name
nerfid-25-mg-capsule
Manufacturer
PharmaCorp Global
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nerfid 25 mg capsule | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Nerfid 25 mg capsule is an antidepressant and anxiolytic medication used to treat major depressive disorder and generalized anxiety disorder. It belongs to the class of serotonin-norepinephrine reuptake inhibitors (SNRIs).
Uses & Indications
Dosage
Adults
Initial dose 25 mg once daily, may be increased to 50 mg daily after 1-2 weeks based on response. Max 100 mg/day.
Elderly
Start with 25 mg once daily, monitor closely for adverse effects. Max 50 mg/day.
Renal_impairment
Mild to moderate: No dose adjustment needed. Severe: Reduce dose by 50%.
How to Take
Take orally with or without food, preferably at the same time each day.
Mechanism of Action
Nerfid selectively inhibits the reuptake of both serotonin and norepinephrine in the central nervous system, thereby increasing the concentrations of these neurotransmitters in the synaptic cleft. This leads to an improvement in mood and a reduction in anxiety symptoms.
Pharmacokinetics
Onset
Initial antidepressant effects may be seen within 1-2 weeks; full effects within 4-6 weeks.
Excretion
Mainly renal, with about 70% excreted as metabolites and 5% as unchanged drug within 72 hours.
Half life
Approximately 10-15 hours.
Absorption
Well absorbed orally, with peak plasma concentrations reached within 2-4 hours.
Metabolism
Primarily hepatic via CYP2D6 and CYP3A4, with active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Nerfid or any excipients
- Concurrent use with MAOIs (Monoamine Oxidase Inhibitors)
- Uncontrolled narrow-angle glaucoma
Drug Interactions
MAOIs
Concurrent use is contraindicated due to risk of serotonin syndrome.
SSRIs
Increased risk of serotonin syndrome.
Alcohol
May potentiate CNS depressant effects.
Warfarin
May increase anticoagulant effect, monitor INR.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, tachycardia, tremor, and seizures. Management is supportive and symptomatic; maintain airway, monitor cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to potential excretion in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Nerfid or any excipients
- Concurrent use with MAOIs (Monoamine Oxidase Inhibitors)
- Uncontrolled narrow-angle glaucoma
Drug Interactions
MAOIs
Concurrent use is contraindicated due to risk of serotonin syndrome.
SSRIs
Increased risk of serotonin syndrome.
Alcohol
May potentiate CNS depressant effects.
Warfarin
May increase anticoagulant effect, monitor INR.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, tachycardia, tremor, and seizures. Management is supportive and symptomatic; maintain airway, monitor cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to potential excretion in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent protected (expires 2030)
Clinical Trials
Extensive Phase I, II, and III clinical trials demonstrated efficacy and safety in major depressive disorder and generalized anxiety disorder, involving over 5,000 patients.
Lab Monitoring
- Liver function tests (baseline and periodically)
- Renal function tests
- Serum sodium (especially in elderly)
Doctor Notes
- Emphasize gradual dose titration to minimize side effects.
- Monitor for signs of serotonin syndrome, especially when co-administered with other serotonergic agents.
- Regular follow-up is crucial for assessing treatment response and managing adverse effects.
Patient Guidelines
- Take consistently as prescribed.
- Do not stop abruptly without consulting your doctor.
- Report any new or worsening symptoms, especially mood changes or suicidal thoughts.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; use caution when driving or operating machinery until you know how Nerfid affects you.
Lifestyle Advice
- Maintain a healthy diet and exercise routine.
- Limit alcohol consumption.
- Practice stress-reduction techniques.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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