Neugalin
Generic Name
Pregabalin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neugalin 25 mg capsule | ৳ 10.00 | ৳ 100.00 |
| neugalin 50 mg capsule | ৳ 14.60 | ৳ 146.00 |
| neugalin 75 mg capsule | ৳ 18.45 | ৳ 184.50 |
| neugalin 150 mg capsule | ৳ 30.10 | ৳ 301.00 |
Description
Overview of the medicine
Neugalin (Pregabalin) is an antiepileptic drug also used to treat neuropathic pain, fibromyalgia, and generalized anxiety disorder. It works by affecting certain chemicals in the brain that send pain signals across the nervous system.
Uses & Indications
Dosage
Adults
Initial dose usually 75 mg twice daily or 50 mg three times daily, adjusted based on response and tolerability, up to a maximum of 300 mg twice daily or 200 mg three times daily (total 600 mg/day).
Elderly
Lower initial doses and slower titration may be required due to potential decreased renal function.
Renal_impairment
Dosage adjustment is necessary for patients with impaired renal function based on creatinine clearance.
How to Take
Take orally with or without food. Swallow the capsule whole with water. Do not chew or crush.
Mechanism of Action
Pregabalin binds with high affinity to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, which modulates the release of excitatory neurotransmitters like glutamate, noradrenaline, and substance P. This action is believed to be responsible for its anticonvulsant, analgesic, and anxiolytic effects.
Pharmacokinetics
Onset
Analgesic effects may be seen within 1 week for neuropathic pain. Anxiolytic effects may be noted within 1 week.
Excretion
Primarily excreted unchanged by the kidneys.
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations occur within 1.5 hours.
Metabolism
Negligibly metabolized in humans; approximately 98% is excreted unchanged in the urine.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
- Severe allergic reactions to previous doses.
Drug Interactions
CNS depressants (opioids, benzodiazepines, alcohol)
May potentiate the sedative and cognitive effects of pregabalin.
Thiazolidinedione antidiabetic agents (e.g., rosiglitazone)
May increase the risk of peripheral edema and weight gain.
Storage
Store below 30°C, protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Management is supportive and symptomatic; hemodialysis may be effective.
Pregnancy & Lactation
Pregnancy Category C: Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
- Severe allergic reactions to previous doses.
Drug Interactions
CNS depressants (opioids, benzodiazepines, alcohol)
May potentiate the sedative and cognitive effects of pregabalin.
Thiazolidinedione antidiabetic agents (e.g., rosiglitazone)
May increase the risk of peripheral edema and weight gain.
Storage
Store below 30°C, protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Management is supportive and symptomatic; hemodialysis may be effective.
Pregnancy & Lactation
Pregnancy Category C: Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generics available (original patent expired)
Clinical Trials
Extensive clinical trials have established pregabalin's efficacy and safety for its approved indications.
Lab Monitoring
- Routine laboratory monitoring is not typically required. Monitor renal function in patients with renal impairment.
Doctor Notes
- Counsel patients on potential CNS depressive effects and avoid abrupt discontinuation.
- Monitor for signs of misuse or dependence, especially in patients with a history of substance abuse.
- Adjust dose carefully in patients with renal impairment.
Patient Guidelines
- Do not stop taking Neugalin suddenly, as this can cause withdrawal symptoms. Consult your doctor before discontinuing.
- Avoid alcohol while taking this medicine.
- Report any unusual mood changes or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness, somnolence, and blurred vision, which could impair driving or operating machinery. Exercise caution.
Lifestyle Advice
- Initial treatment may cause dizziness or drowsiness, so avoid driving or operating heavy machinery until you know how the medicine affects you.
- Maintain a healthy lifestyle and discuss any concerns with your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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