Medicine Information

Neurega

Name: Neurega
Brand: Neurega

Capsule100 mgNeuropathic pain, Anticonvulsant, AnxiolyticATC: N03AX16

Generic Name

Pregabalin 100 mg

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
neurega 100 mg capsule	৳ 22.00	৳ 88.00

Description

Overview of the medicine

Neurega 100 mg Capsule contains Pregabalin, which is an antiepileptic and neuropathic pain medication. It is used to treat neuropathic pain, epilepsy (partial seizures), generalized anxiety disorder, and fibromyalgia.

Uses & Indications

Neuropathic pain (diabetic peripheral neuropathy, post-herpetic neuralgia, spinal cord injury associated neuropathic pain)

Adjunctive therapy for partial onset seizures in adults

Generalized Anxiety Disorder (GAD) in adults

Fibromyalgia

Dosage

Adults

Initial dose of 75 mg twice daily or 50 mg three times daily, adjusted according to response and tolerability, up to a maximum of 300 mg twice daily (600 mg/day).

Elderly

Dose adjustment may be necessary in elderly patients due to potentially decreased renal function. Start with a lower dose.

Renal_impairment

Dose must be individualized based on creatinine clearance (CrCl). Lower doses are required for patients with CrCl < 60 mL/min.

How to Take

Neurega capsules should be taken orally, with or without food. Swallow the capsule whole with water.

Mechanism of Action

Pregabalin binds with high affinity to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding reduces the release of several neurotransmitters, including glutamate, norepinephrine, and substance P, thereby decreasing neuronal excitability and pain signaling.

Pharmacokinetics

Onset

Onset of analgesic effect often within 1 week for neuropathic pain. Anxiolytic effects may appear sooner.

Excretion

Excreted almost entirely unchanged in the urine (approximately 98%).

Half life

Approximately 6.3 hours.

Absorption

Rapidly absorbed after oral administration; peak plasma concentrations reached within 1.5 hours.

Metabolism

Negligible hepatic metabolism; does not induce or inhibit drug-metabolizing enzymes.

Side Effects

Contraindications

Hypersensitivity to pregabalin or any component of the formulation.
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.

Drug Interactions

ACE Inhibitors

Increased risk of angioedema when co-administered with pregabalin.

Opioids, Benzodiazepines, Alcohol

May enhance the central nervous system (CNS) depressant effects, increasing risk of drowsiness, sedation, and respiratory depression.

Storage

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include somnolence, confusion, agitation, and rarely, coma. Management is supportive, and hemodialysis may be considered in severe cases.

Pregnancy & Lactation

Pregnancy Category C. Should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in human milk.

Side Effects

Contraindications

Hypersensitivity to pregabalin or any component of the formulation.
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.

Drug Interactions

ACE Inhibitors

Increased risk of angioedema when co-administered with pregabalin.

Opioids, Benzodiazepines, Alcohol

May enhance the central nervous system (CNS) depressant effects, increasing risk of drowsiness, sedation, and respiratory depression.

Storage

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include somnolence, confusion, agitation, and rarely, coma. Management is supportive, and hemodialysis may be considered in severe cases.

Pregnancy & Lactation

Pregnancy Category C. Should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in human milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules20 capsules30 capsules

Shelf Life

24 to 36 months from manufacturing date.

Availability

Pharmacies nationwide

Approval Status

Approved

Patent Status

Generic available

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of pregabalin for its approved indications, including neuropathic pain, epilepsy, GAD, and fibromyalgia.

Lab Monitoring

No routine lab monitoring is required. Renal function should be monitored, especially in elderly patients or those with pre-existing renal impairment, to adjust dosage.

Doctor Notes

Emphasize the importance of gradual dose tapering to prevent withdrawal symptoms.
Counsel patients on potential CNS depressant effects, especially with concomitant use of other CNS depressants (e.g., opioids, benzodiazepines, alcohol).
Monitor for emergent psychiatric symptoms, including suicidal thoughts or behaviors.

Patient Guidelines

Do not stop taking Neurega abruptly, as this may lead to withdrawal symptoms. Always consult your doctor for dose reduction.
Avoid alcohol consumption while on this medication, as it may enhance dizziness and drowsiness.
Report any unusual mood changes, suicidal thoughts, or signs of allergic reactions (e.g., swelling of face, lips, tongue) to your doctor immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Neurega may cause dizziness, somnolence, and blurred vision, which could impair your ability to drive or operate machinery. Exercise caution until you know how the medicine affects you.