Administer by deep intramuscular injection or by slow intravenous infusion (over 30 minutes) or slow intravenous injection (over 2-4 minutes). Reconstitute with appropriate diluents (e.g., sterile water for injection, lidocaine solution for IM).

Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.

• •Hypersensitivity to ceftriaxone or any other cephalosporins
• •Neonates with hyperbilirubinemia, especially premature infants
• •Neonates requiring calcium-containing IV solutions (due to precipitation risk)

Store below 30°C in a dry place, away from light. Do not freeze. Reconstituted solution should be used immediately or within 24 hours if refrigerated.

Symptoms of overdose may include nausea, vomiting, diarrhea, and central nervous system effects (e.g., convulsions) in susceptible individuals. Management is symptomatic and supportive; hemodialysis or peritoneal dialysis is not effective in removing ceftriaxone.

Pregnancy Category B. Studies in animals have shown no evidence of fetal harm, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Excreted in low concentrations in breast milk; caution is advised when administering to a nursing mother.