Nixon
Generic Name
Nixicillin
Manufacturer
MediTech Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nixon 250 mg injection | ৳ 110.33 | N/A |
Description
Overview of the medicine
Nixon 250 mg Injection contains Nixicillin, a broad-spectrum third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
250 mg to 1 g every 8-12 hours, depending on infection severity.
Elderly
No specific dose adjustment required unless renal impairment is present.
Renal_impairment
Dose reduction necessary for creatinine clearance < 30 mL/min.
How to Take
For intramuscular (IM) or intravenous (IV) administration. For IV, administer slowly over 30-60 minutes.
Mechanism of Action
Nixicillin works by inhibiting bacterial cell wall synthesis, leading to cell lysis and bacterial death. It binds to penicillin-binding proteins (PBPs) located on the bacterial cell membrane.
Pharmacokinetics
Onset
Within 15-30 minutes (IV), 30-60 minutes (IM)
Excretion
Primarily excreted unchanged by the kidneys (glomerular filtration and tubular secretion).
Half life
Approximately 1.5-2.5 hours
Absorption
Rapid and complete absorption after intramuscular (IM) or intravenous (IV) administration. Peak plasma concentrations are achieved within 0.5-2 hours.
Metabolism
Minimally metabolized in the liver (less than 10%).
Side Effects
Contraindications
- •Hypersensitivity to cephalosporins or penicillins
- •Severe renal impairment without dose adjustment
Drug Interactions
Aminoglycosides
Concurrent use may increase nephrotoxicity.
Diuretics (e.g., Furosemide)
May increase the risk of nephrotoxicity.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Reconstituted solution should be used immediately.
Overdose
Management is symptomatic and supportive. Hemodialysis may be helpful in severe cases.
Pregnancy & Lactation
Use with caution; consult a doctor. Excreted in breast milk in small amounts, monitor infant for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved by DGDA
Patent Status
Patent expired
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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