For IV administration, reconstitute with sterile water for injection and administer slowly over 30 minutes. For IM, reconstitute with lidocaine 1% solution and inject deeply into a large muscle.

Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.

• •Hypersensitivity to Ceftriaxone or other cephalosporins
• •Neonates (especially premature) with hyperbilirubinemia
• •Concomitant use with calcium-containing IV solutions in neonates

Store below 30°C. Protect from light. Keep out of reach of children. Reconstituted solution is stable for a limited time.

Symptoms may include nausea, vomiting, diarrhea, and convulsions. Management involves symptomatic and supportive treatment; hemodialysis or peritoneal dialysis is not effective.

Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in low concentrations; use with caution during lactation.