Omegut
Generic Name
Omeprazole
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| omegut 20 mg capsule | ৳ 5.00 | ৳ 50.00 |
| omegut 40 mg capsule | ৳ 7.03 | ৳ 70.30 |
| omegut 40 mg injection | ৳ 80.00 | N/A |
Description
Overview of the medicine
Omeprazole is a proton pump inhibitor (PPI) that decreases the amount of acid produced in the stomach. It is used to treat conditions such as gastroesophageal reflux disease (GERD), ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
20-40 mg once daily, usually in the morning, for 4-8 weeks depending on the condition.
Elderly
No specific dose adjustment for elderly patients, but consider renal or hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with renal impairment.
How to Take
Take the capsule whole with a glass of water, preferably in the morning before a meal. Do not chew or crush.
Mechanism of Action
Omeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby suppressing gastric acid secretion.
Pharmacokinetics
Onset
Onset of acid suppression within 1 hour, with maximal effect achieved after 2-3 days of continuous therapy.
Excretion
Approximately 80% of metabolites are excreted in the urine and 20% in the feces.
Half life
Plasma elimination half-life is approximately 0.5-1 hour, but the duration of acid suppression is much longer (up to 72 hours) due to irreversible binding.
Absorption
Rapidly absorbed after leaving the stomach, with peak plasma concentrations occurring 1-2 hours after administration of enteric-coated capsules.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
May increase INR and bleeding risk.
Nelfinavir
Reduced plasma levels of nelfinavir.
Clopidogrel
May reduce antiplatelet effect of clopidogrel.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and transient (e.g., nausea, vomiting, dizziness, abdominal pain). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in human milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
May increase INR and bleeding risk.
Nelfinavir
Reduced plasma levels of nelfinavir.
Clopidogrel
May reduce antiplatelet effect of clopidogrel.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and transient (e.g., nausea, vomiting, dizziness, abdominal pain). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in human milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in all pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of omeprazole for various acid-related disorders.
Lab Monitoring
- No routine lab monitoring is generally required. However, prolonged use may necessitate monitoring of vitamin B12 levels.
- Monitor magnesium levels in patients on prolonged therapy, especially with diuretics.
Doctor Notes
- Consider lowest effective dose for shortest duration.
- Review necessity for continued PPI therapy periodically.
- Counsel patients on potential long-term risks, especially for elderly or those with comorbidities.
Patient Guidelines
- Take exactly as prescribed, do not stop abruptly without consulting your doctor.
- Swallow capsules whole, do not chew or crush.
- Report any unusual symptoms to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; use caution when driving or operating machinery.
Lifestyle Advice
- Avoid spicy foods, caffeine, and alcohol if they worsen symptoms.
- Eat smaller, more frequent meals.
- Elevate the head of your bed to reduce nighttime reflux.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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