Onepro
Generic Name
Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| onepro 20 mg capsule | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Onepro 20 mg Capsule contains Esomeprazole, a proton pump inhibitor used to reduce stomach acid production and treat conditions like GERD and ulcers.
Uses & Indications
Dosage
Adults
For GERD: 20 mg or 40 mg once daily for 4-8 weeks. For Erosive Esophagitis: 20 mg or 40 mg once daily for 4-8 weeks. For H. pylori Eradication: 20 mg twice daily for 10 days (in combination with antibiotics).
Elderly
No specific dose adjustment is required, but caution is advised due to potential age-related decrease in liver function.
Renal_impairment
No dosage adjustment is necessary for patients with impaired renal function.
How to Take
Take the capsule whole with water at least one hour before a meal. Do not chew or crush the capsule. If swallowing is difficult, the capsule can be opened and the contents mixed with a small amount of water or fruit juice (do not store the mixture).
Mechanism of Action
Esomeprazole selectively binds to and irreversibly inhibits the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby suppressing gastric acid secretion.
Pharmacokinetics
Onset
Acid suppression typically begins within 1 hour after oral administration.
Excretion
Primarily via urine (approximately 80%) as metabolites and feces (approximately 20%).
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration; bioavailability is approximately 64% after a single dose and 89% after repeated once-daily dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- •Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- •Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time; monitor closely for bleeding.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel (clinical significance debated); use with caution.
Methotrexate
Increased methotrexate levels, especially with high doses; consider temporary PPI discontinuation.
Nelfinavir, Atazanavir
Decreased plasma levels of antivirals due to increased gastric pH, leading to potential loss of virologic response.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms are generally mild and self-limiting (e.g., drowsiness, tachycardia, nausea, diarrhea, headache). Treatment is symptomatic and supportive; no specific antidote is available.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Esomeprazole is excreted in human breast milk; use with caution during lactation and consider the benefits of breastfeeding versus potential risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, patent expired for original formulation
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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