Onepro
Generic Name
Omeprazole
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| onepro 40 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Onepro 40 mg Tablet is a proton pump inhibitor (PPI) used to reduce stomach acid production. It treats conditions like heartburn, gastroesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Typically 20-40 mg once daily, depending on the condition. For GERD, 20 mg once daily for 4-8 weeks. For duodenal ulcers, 20 mg once daily for 2-4 weeks. For gastric ulcers, 20 mg once daily for 4-8 weeks. For Zollinger-Ellison Syndrome, initial dose 60 mg once daily, adjusted as needed.
Elderly
No specific dose adjustment is generally required, but caution should be exercised.
Renal_impairment
No dose adjustment is needed for patients with impaired renal function.
How to Take
Take the tablet whole with a glass of water, preferably in the morning before food. Do not chew or crush.
Mechanism of Action
Omeprazole inhibits the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells, thereby blocking the final step of acid production.
Pharmacokinetics
Onset
Acid secretion inhibition occurs within 1 hour, maximal effect within 2 hours.
Excretion
Mainly excreted in urine (approx. 77%) and feces (approx. 18%).
Half life
Plasma half-life is approximately 0.5-1 hour, but duration of acid suppression is much longer (up to 72 hours) due to irreversible binding.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 0.5-3.5 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any components of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Digoxin
Increased bioavailability of digoxin.
Diazepam
Decreased metabolism and increased plasma levels of diazepam.
Warfarin
Increased INR/prothrombin time.
Clopidogrel
Reduced effectiveness of clopidogrel (avoid concomitant use or monitor closely).
Methotrexate
Increased plasma levels of methotrexate.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any components of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Digoxin
Increased bioavailability of digoxin.
Diazepam
Decreased metabolism and increased plasma levels of diazepam.
Warfarin
Increased INR/prothrombin time.
Clopidogrel
Reduced effectiveness of clopidogrel (avoid concomitant use or monitor closely).
Methotrexate
Increased plasma levels of methotrexate.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established omeprazole's efficacy and safety in various acid-related disorders since its introduction. Ongoing research explores long-term effects and new indications.
Lab Monitoring
- Electrolytes (if prolonged use)
- Liver function tests (in specific cases)
- Vitamin B12 levels (for long-term use)
Doctor Notes
- Advise patients to take before meals.
- Monitor patients on long-term therapy for potential vitamin B12 deficiency and bone health.
- Educate patients about the risk of *Clostridium difficile* infection.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine abruptly.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; exercise caution when driving or operating machinery.
Lifestyle Advice
- Avoid spicy and fatty foods.
- Eat smaller, more frequent meals.
- Elevate the head of your bed to reduce reflux symptoms.
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Global Brand Names
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