Onepro
Generic Name
Esomeprazole 40 mg
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| onepro 40 mg capsule | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Onepro 40 mg capsule contains Esomeprazole, a proton pump inhibitor that reduces the amount of acid produced in the stomach. It is used to treat conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers.
Uses & Indications
Dosage
Adults
For most conditions, 20-40 mg once daily, usually taken at least one hour before a meal. Duration of treatment varies based on indication (e.g., GERD 4-8 weeks). For Zollinger-Ellison Syndrome, initial dose is typically 40 mg twice daily, adjusted as needed.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
How to Take
Take the capsule orally, usually at least one hour before a meal. Swallow the capsule whole with water; do not chew or crush it. If you have difficulty swallowing, the capsule can be opened and the pellets mixed with a small amount of water or soft food (e.g., apple sauce) and swallowed immediately.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase enzyme system (the 'proton pump') in the gastric parietal cells. This irreversible inhibition reduces gastric acid secretion by blocking the final step of acid production.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Excreted mainly in urine (approximately 80%) and feces (approximately 20%) as metabolites.
Half life
Approximately 1.5 hours (plasma half-life, but duration of acid suppression is much longer)
Absorption
Rapidly absorbed after oral administration, peak plasma concentration reached within 1-2 hours. Bioavailability is approximately 50-68% (single dose).
Metabolism
Extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir (an antiretroviral drug).
Drug Interactions
Warfarin
Increased INR and prothrombin time; careful monitoring is recommended.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to inhibition of CYP2C19.
Methotrexate
May increase serum levels of methotrexate, leading to potential toxicity, especially at high doses.
HIV Antivirals (e.g., Nelfinavir, Atazanavir)
Reduced absorption and plasma concentrations of these drugs, potentially leading to loss of efficacy. Concomitant use with nelfinavir is contraindicated.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include lethargy, confusion, blurred vision, tachycardia, nausea, sweating, flushing, headache, and dry mouth. Treatment is symptomatic and supportive. Esomeprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Esomeprazole is likely excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir (an antiretroviral drug).
Drug Interactions
Warfarin
Increased INR and prothrombin time; careful monitoring is recommended.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to inhibition of CYP2C19.
Methotrexate
May increase serum levels of methotrexate, leading to potential toxicity, especially at high doses.
HIV Antivirals (e.g., Nelfinavir, Atazanavir)
Reduced absorption and plasma concentrations of these drugs, potentially leading to loss of efficacy. Concomitant use with nelfinavir is contraindicated.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include lethargy, confusion, blurred vision, tachycardia, nausea, sweating, flushing, headache, and dry mouth. Treatment is symptomatic and supportive. Esomeprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Esomeprazole is likely excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, specific to manufacturer.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety for various acid-related disorders, including GERD, erosive esophagitis, and H. pylori eradication. These trials have shown it to be effective in healing erosions and providing symptomatic relief.
Lab Monitoring
- Serum magnesium levels (especially in patients on long-term therapy or concomitant diuretics)
- Liver function tests (if liver impairment is suspected or develops)
Doctor Notes
- Consider lowest effective dose and shortest duration of therapy.
- Monitor for signs of C. difficile infection if diarrhea develops.
- Assess magnesium levels in patients on prolonged therapy or concomitant diuretics.
- Review necessity of continued PPI therapy periodically.
Patient Guidelines
- Take the capsule whole; do not chew, crush, or open it (unless directed by your doctor for administration reasons).
- Take at least one hour before a meal.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Do not stop taking the medicine suddenly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Esomeprazole generally has no or negligible influence on the ability to drive and use machines. However, side effects like dizziness or blurred vision may occur infrequently, which could impair reactions. Patients experiencing such effects should avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods (e.g., spicy foods, caffeine, fatty foods, citrus fruits).
- Elevate the head of your bed to reduce reflux symptoms.
- Avoid smoking and excessive alcohol consumption.
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