OnePro
Generic Name
Omeprazole
Manufacturer
ACME Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| onepro 20 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Omeprazole is a proton pump inhibitor used to treat gastroesophageal reflux disease (GERD), ulcers, and other conditions caused by excess stomach acid.
Uses & Indications
Dosage
Adults
GERD: 20 mg once daily for 4-8 weeks. Duodenal Ulcer: 20 mg once daily for 2-4 weeks. Gastric Ulcer: 20 mg once daily for 4-8 weeks. Zollinger-Ellison Syndrome: Initial 60 mg once daily.
Elderly
No specific dosage adjustment usually required, but caution advised due to potential decreased metabolism.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment. For severe impairment, caution is advised.
How to Take
Take orally, preferably in the morning before a meal. Swallow the tablet whole; do not chew or crush.
Mechanism of Action
Irreversibly binds to and inhibits the H+/K+-ATPase (proton pump) in gastric parietal cells, blocking the final step of acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly via urine (approx. 80%) and feces (approx. 20%).
Half life
0.5-1 hour (increases with liver impairment)
Absorption
Rapidly absorbed from the GI tract after oral administration. Bioavailability approx. 30-40%.
Metabolism
Extensively metabolized in the liver via CYP2C19 and CYP3A4.
Side Effects
Contraindications
- •Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- •Concomitant use with nelfinavir.
Drug Interactions
Diazepam
Increased plasma levels of diazepam.
Warfarin
Increased INR/bleeding risk.
Clopidogrel
Omeprazole can reduce the antiplatelet effect of clopidogrel by inhibiting its activation.
Methotrexate
Increased plasma levels of methotrexate, especially with high doses.
Nelfinavir/Atazanavir
Reduced plasma levels of antiretrovirals, potentially leading to loss of virologic response.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, dizziness, abdominal pain, diarrhea, headache. Treatment is symptomatic and supportive. Omeprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk. Small amounts excreted in breast milk; use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major regulatory bodies globally
Patent Status
Generic available (Patent expired)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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