Onlit
Generic Name
Ondansetron
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| onlit 8 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery.
Uses & Indications
Dosage
Adults
For chemotherapy: 8 mg orally twice daily. For radiation: 8 mg 1-2 hours before therapy. For PONV: 16 mg orally 1 hour before anesthesia.
Elderly
No general dosage adjustment required; monitor hepatic/renal function.
Renal_impairment
No dosage adjustment needed. For severe hepatic impairment, maximum 8 mg/day.
How to Take
Swallow the tablet whole with a glass of water, with or without food. Do not chew or crush.
Mechanism of Action
Ondansetron is a selective 5-HT3 receptor antagonist. It blocks serotonin, a natural substance in the body that can cause nausea and vomiting. It primarily works in the gastrointestinal tract and the chemoreceptor trigger zone (CTZ) in the brain.
Pharmacokinetics
Onset
Within 30 minutes for oral administration.
Excretion
Primarily excreted in urine (about 5-10% as unchanged drug) and feces (via bile).
Half life
Approximately 3-5 hours.
Absorption
Rapidly and completely absorbed from the GI tract after oral administration, but undergoes first-pass metabolism. Bioavailability is about 60%.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (CYP1A2, CYP2D6, CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to ondansetron or any component of the formulation.
- Concomitant use with apomorphine.
Drug Interactions
Apomorphine
Increased risk of severe hypotension and loss of consciousness.
QT-prolonging drugs
Increased risk of QT interval prolongation, leading to potential arrhythmias.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include visual disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted into breast milk in animals; exercise caution when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to ondansetron or any component of the formulation.
- Concomitant use with apomorphine.
Drug Interactions
Apomorphine
Increased risk of severe hypotension and loss of consciousness.
QT-prolonging drugs
Increased risk of QT interval prolongation, leading to potential arrhythmias.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include visual disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted into breast milk in animals; exercise caution when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support its efficacy and safety in preventing chemotherapy, radiation, and post-operative induced nausea and vomiting.
Lab Monitoring
- ECG monitoring in patients with cardiac risk factors.
- Liver function tests in patients with hepatic impairment.
Doctor Notes
- Monitor ECG in patients with congenital long QT syndrome or other cardiac conditions.
- Consider dose reduction in severe hepatic impairment.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not share this medicine with others.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or fatigue. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment as it may worsen side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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