Pred
Generic Name
Prednisolone 10 mg Tablet
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pred 10 mg tablet | ৳ 3.23 | ৳ 32.30 |
Description
Overview of the medicine
Prednisolone is a synthetic corticosteroid drug used for its anti-inflammatory and immunosuppressant effects. It is used to treat a wide range of conditions including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.
Uses & Indications
Dosage
Adults
Dosage varies widely depending on the condition being treated and patient response. Initial doses typically range from 5-60 mg daily, usually given in divided doses or as a single daily dose. Tapering is crucial after long-term therapy.
Elderly
Lower initial doses may be considered, and patients should be monitored for adverse effects. Consider co-morbidities.
Renal_impairment
No specific dose adjustment is generally required, but monitor for fluid retention and electrolyte disturbances.
How to Take
Take orally, usually with food or milk to minimize gastrointestinal irritation. Follow your doctor's instructions regarding dose and duration. Do not stop suddenly.
Mechanism of Action
Prednisolone binds to intracellular glucocorticoid receptors and modifies gene expression. This leads to the synthesis of anti-inflammatory proteins and the inhibition of pro-inflammatory mediators, thereby reducing inflammation and suppressing the immune response.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within hours, but full therapeutic effect may take days.
Excretion
Excreted mainly in the urine, predominantly as inactive metabolites.
Half life
Plasma half-life is 2-4 hours; biological half-life is 18-36 hours.
Absorption
Well absorbed from the gastrointestinal tract after oral administration.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines to immunocompromised patients
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration and bleeding.
Warfarin
Altered anticoagulant effects; monitor INR.
Live vaccines
Increased risk of infection in immunosuppressed patients.
Antidiabetic agents
May increase blood glucose levels, requiring dose adjustment of antidiabetic drugs.
Diuretics (thiazide, loop)
Increased risk of hypokalemia.
Phenytoin, Barbiturates, Rifampicin
May decrease corticosteroid effects by inducing hepatic metabolism.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare and generally does not cause life-threatening problems. Symptoms may include fluid retention, hypertension, hypokalemia, and hyperglycemia. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; caution should be exercised when administered to a nursing mother. Monitor the infant for adverse effects.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines to immunocompromised patients
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration and bleeding.
Warfarin
Altered anticoagulant effects; monitor INR.
Live vaccines
Increased risk of infection in immunosuppressed patients.
Antidiabetic agents
May increase blood glucose levels, requiring dose adjustment of antidiabetic drugs.
Diuretics (thiazide, loop)
Increased risk of hypokalemia.
Phenytoin, Barbiturates, Rifampicin
May decrease corticosteroid effects by inducing hepatic metabolism.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare and generally does not cause life-threatening problems. Symptoms may include fluid retention, hypertension, hypokalemia, and hyperglycemia. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; caution should be exercised when administered to a nursing mother. Monitor the infant for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved (e.g., FDA/DGDA)
Patent Status
Off-patent, generic available
WHO Essential Medicine
YesClinical Trials
Prednisolone is a well-established medicine with extensive clinical evidence. Ongoing trials often focus on new indications, optimized dosing regimens, or comparison with newer agents.
Lab Monitoring
- Blood glucose levels (especially in diabetics)
- Electrolytes (potassium)
- Blood pressure
- Bone mineral density (for long-term use)
- Ophthalmologic exams (for long-term use)
Doctor Notes
- Emphasize the importance of gradual dose tapering to prevent adrenal crisis.
- Advise patients on infection prevention strategies due to immunosuppression.
- Monitor for bone density loss, hyperglycemia, and ocular changes during prolonged therapy.
Patient Guidelines
- Take exactly as prescribed; do not stop abruptly without consulting your doctor.
- Report any unusual side effects or worsening of your condition.
- Avoid close contact with people who have infections (e.g., chickenpox, measles).
- Carry a steroid card if on long-term therapy.
- Monitor blood sugar if you have diabetes.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Prednisolone generally does not affect the ability to drive or operate machinery. However, if you experience dizziness, blurred vision, or mood changes, avoid such activities.
Lifestyle Advice
- Maintain a healthy diet to manage weight and blood sugar.
- Ensure adequate calcium and Vitamin D intake for bone health.
- Engage in regular, moderate exercise if possible.
- Avoid smoking and excessive alcohol consumption.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Pred Brand
Other medicines available under the same brand name
