Pred
Generic Name
Prednisolone
Manufacturer
Generic Manufacturer
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pred 20 mg tablet | ৳ 6.27 | ৳ 62.70 |
Description
Overview of the medicine
Prednisolone 20 mg tablet is a synthetic corticosteroid used to treat a wide range of inflammatory and autoimmune conditions. It works by decreasing the body's immune response to various diseases to reduce symptoms such as swelling, pain, and allergic-type reactions.
Uses & Indications
Dosage
Adults
Initial dose typically 5-60 mg daily, adjusted based on response. Tapering often required for long-term use.
Elderly
Use with caution, may require lower doses due to increased risk of side effects.
Renal_impairment
No specific dose adjustment generally needed, but monitor closely.
How to Take
Administer orally, usually once daily in the morning, with food or milk to minimize gastrointestinal irritation. Do not stop abruptly, especially after prolonged use.
Mechanism of Action
Prednisolone binds to intracellular glucocorticoid receptors, forming a complex that translocates into the nucleus and modulates gene expression. This leads to widespread anti-inflammatory and immunosuppressive effects by inhibiting the release of inflammatory mediators and suppressing immune cell function.
Pharmacokinetics
Onset
Hours to days, depending on condition.
Excretion
Renal (metabolites).
Half life
Plasma half-life 2-4 hours; biological half-life 18-36 hours.
Absorption
Well absorbed orally. Peak plasma concentrations in 1-3 hours.
Metabolism
Hepatic, primarily to inactive metabolites.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to prednisolone or any component of the formulation
- Active untreated infections
Drug Interactions
NSAIDs
Increased risk of GI bleeding.
Diuretics
Increased potassium loss.
Anticoagulants
May alter anticoagulant effect.
Insulin/Oral Hypoglycemics
May increase blood glucose levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include mood changes, fluid retention, or hypertension. Treatment is symptomatic and supportive. Chronic overdose leads to Cushing's syndrome.
Pregnancy & Lactation
Category C in pregnancy. Use only if potential benefit justifies potential risk to the fetus. Prednisolone is excreted in breast milk; caution should be exercised. Consult a doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to prednisolone or any component of the formulation
- Active untreated infections
Drug Interactions
NSAIDs
Increased risk of GI bleeding.
Diuretics
Increased potassium loss.
Anticoagulants
May alter anticoagulant effect.
Insulin/Oral Hypoglycemics
May increase blood glucose levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include mood changes, fluid retention, or hypertension. Treatment is symptomatic and supportive. Chronic overdose leads to Cushing's syndrome.
Pregnancy & Lactation
Category C in pregnancy. Use only if potential benefit justifies potential risk to the fetus. Prednisolone is excreted in breast milk; caution should be exercised. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Patent Expired
WHO Essential Medicine
YesClinical Trials
Prednisolone has been extensively studied in numerous clinical trials over several decades for its efficacy and safety across various inflammatory and autoimmune conditions.
Lab Monitoring
- Blood glucose levels
- Electrolyte balance (especially potassium)
- Blood pressure
- Bone mineral density (for long-term use)
- Regular eye examinations (for glaucoma/cataracts)
Doctor Notes
- Emphasize the importance of gradual dose tapering to avoid adrenal crisis.
- Monitor patients for signs of infection, blood glucose abnormalities, bone density changes, and ophthalmic complications during long-term therapy.
Patient Guidelines
- Take exactly as prescribed.
- Do not stop taking this medication abruptly without consulting your doctor, especially after prolonged use, as it can lead to withdrawal symptoms.
- Report any unusual side effects or signs of infection.
- Monitor blood sugar levels if diabetic.
- Avoid close contact with people who have infections like chickenpox or measles.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Prednisolone may cause dizziness or blurred vision in some individuals. If these effects occur, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet, potentially including calcium and vitamin D supplements, to counteract bone loss.
- Engage in moderate exercise.
- Avoid excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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