Primocef
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| primocef 125 mg suspension | ৳ 198.00 | N/A |
Description
Overview of the medicine
Cefixime is an oral third-generation cephalosporin antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Adults: Typically 200-400 mg once daily or 200 mg twice daily (for tablets/capsules). For children (6 months to 12 years) using suspension: 8 mg/kg/day orally, as a single dose or in two divided doses for 5-10 days.
Elderly
No specific dosage adjustment required for elderly patients unless renal impairment is present.
Renal_impairment
Dosage adjustment is necessary for patients with creatinine clearance less than 60 mL/min.
How to Take
Can be taken with or without food. Shake the bottle well before each use. Use the provided measuring spoon or cup to ensure accurate dosing.
Mechanism of Action
It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Typically within 1-2 hours.
Excretion
Renal excretion (approx. 50% of absorbed dose).
Half life
About 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food slightly prolongs Tmax but does not significantly affect the extent of absorption.
Metabolism
Not extensively metabolized. Primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reaction to penicillin.
Drug Interactions
Nifedipine
Concurrent use may increase cefixime absorption.
Carbamazepine
Cefixime may increase carbamazepine levels. Monitor carbamazepine levels.
Warfarin and other anticoagulants
May increase prothrombin time (INR) and risk of bleeding. Close monitoring is advised.
Storage
Store the dry powder at room temperature (below 30°C), protected from light and moisture. Keep the reconstituted suspension refrigerated (2-8°C) and do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Symptomatic and supportive treatment is recommended. Hemodialysis or peritoneal dialysis is not effective in removing cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Should be used during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution in lactating mothers.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reaction to penicillin.
Drug Interactions
Nifedipine
Concurrent use may increase cefixime absorption.
Carbamazepine
Cefixime may increase carbamazepine levels. Monitor carbamazepine levels.
Warfarin and other anticoagulants
May increase prothrombin time (INR) and risk of bleeding. Close monitoring is advised.
Storage
Store the dry powder at room temperature (below 30°C), protected from light and moisture. Keep the reconstituted suspension refrigerated (2-8°C) and do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Symptomatic and supportive treatment is recommended. Hemodialysis or peritoneal dialysis is not effective in removing cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Should be used during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution in lactating mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unopened bottle: 24-36 months from manufacturing date. Reconstituted suspension: 14 days when stored in a refrigerator.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone numerous clinical trials demonstrating its efficacy and safety for treating various bacterial infections in both pediatric and adult populations.
Lab Monitoring
- Periodic assessment of renal function (especially in patients with pre-existing renal impairment).
- Complete blood count (CBC) during prolonged therapy.
Doctor Notes
- Always perform culture and sensitivity tests before initiating therapy, if feasible, to guide appropriate antibiotic selection.
- Educate patients on the importance of completing the full antibiotic course.
- Monitor for signs of hypersensitivity reactions, especially in patients with a history of allergies.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
- Do not share this medicine with others, even if they have similar symptoms.
- Report any severe or persistent diarrhea to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double dose to make up for a missed one.
Driving Precautions
Generally, cefixime does not impair the ability to drive or operate machinery. However, some individuals may experience dizziness, in which case caution is advised.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid self-medication with antibiotics.
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