Primocef
Generic Name
Ceftriaxone
Manufacturer
Square Pharmaceuticals PLC
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| primocef 15 gm injection | ৳ 200.60 | N/A |
Description
Overview of the medicine
Primocef 1.5 gm Injection contains Ceftriaxone, a third-generation cephalosporin antibiotic, used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
Typical adult dose is 1-2 gm intravenously (IV) or intramuscularly (IM) once daily or in two divided doses. Max 4 gm/day.
Elderly
No specific dose adjustment for elderly with normal renal and hepatic function.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. For severe impairment (CrCl <10 mL/min), dose should not exceed 2 gm daily.
How to Take
Administered by slow intravenous (IV) injection over 2-4 minutes, or by deep intramuscular (IM) injection. IV infusion over 30 minutes also possible.
Mechanism of Action
Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Onset within 1 hour after administration.
Excretion
Biliary and renal excretion.
Half life
Approximately 6-9 hours.
Absorption
Rapid and complete absorption after intramuscular (IM) injection. High bioavailability.
Metabolism
Mainly hepatic, with approximately 35-65% excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to ceftriaxone, other cephalosporins, or any component of the formulation
- Hyperbilirubinemic neonates, especially premature infants
- Concomitant use with calcium-containing IV solutions in neonates
Drug Interactions
Aminoglycosides
Synergistic effect, but should not be mixed in the same syringe.
Oral anticoagulants
May increase the anticoagulant effect, requiring INR monitoring.
Calcium-containing solutions
Concomitant use is contraindicated in neonates due to precipitation risk.
Loop diuretics (e.g., Furosemide)
May increase ceftriaxone concentrations.
Storage
Store below 30°C. Protect from light. Reconstituted solution is stable for a specific period (e.g., 6 hours at room temperature, 24 hours refrigerated).
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, and in severe cases, neurological disturbances. Management is symptomatic and supportive; hemodialysis or peritoneal dialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk in low concentrations, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to ceftriaxone, other cephalosporins, or any component of the formulation
- Hyperbilirubinemic neonates, especially premature infants
- Concomitant use with calcium-containing IV solutions in neonates
Drug Interactions
Aminoglycosides
Synergistic effect, but should not be mixed in the same syringe.
Oral anticoagulants
May increase the anticoagulant effect, requiring INR monitoring.
Calcium-containing solutions
Concomitant use is contraindicated in neonates due to precipitation risk.
Loop diuretics (e.g., Furosemide)
May increase ceftriaxone concentrations.
Storage
Store below 30°C. Protect from light. Reconstituted solution is stable for a specific period (e.g., 6 hours at room temperature, 24 hours refrigerated).
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, and in severe cases, neurological disturbances. Management is symptomatic and supportive; hemodialysis or peritoneal dialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk in low concentrations, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when stored as recommended.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Ceftriaxone for various bacterial infections since its introduction.
Lab Monitoring
- Complete blood count (CBC) with differential for prolonged therapy
- Liver and renal function tests
- Coagulation parameters (e.g., PT/INR) if concomitant anticoagulants are used
Doctor Notes
- Ceftriaxone is highly protein-bound, consider in hypoalbuminemia.
- Avoid rapid IV push in neonates, particularly those with hyperbilirubinemia.
- Monitor for signs of superinfection with prolonged use.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Report any severe diarrhea or allergic reactions immediately.
- Do not use for viral infections (e.g., common cold, flu).
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some patients; advise caution when driving or operating machinery until effects are known.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment as it may exacerbate side effects (though not a direct interaction).
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