Medicine Information

Procin

Name: Procin
Brand: Procin
Rating: 4.5 (117 reviews)

Tablet250 mgAntibiotics - FluoroquinolonesATC: J01MA02

Generic Name

Ciprofloxacin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
procin 250 mg tablet	৳ 8.52	N/A

Description

Overview of the medicine

Procin 250 mg Tablet contains Ciprofloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections including urinary tract infections, respiratory tract infections, skin and soft tissue infections, and bone and joint infections.

Uses & Indications

Urinary Tract Infections (UTIs)

Respiratory Tract Infections

Skin and Soft Tissue Infections

Bone and Joint Infections

Gastrointestinal Infections (e.g., infectious diarrhea)

Anthrax (post-exposure)

Dosage

Adults

Typical adult dosage for uncomplicated UTIs is 250 mg twice daily for 3 days; for other infections, 250-750 mg twice daily depending on infection severity and site.

Elderly

Dosage adjustment may be necessary based on renal function.

Renal_impairment

Dose reduction is required for creatinine clearance <50 mL/min.

How to Take

Orally, with or without food. Do not take with dairy products or calcium-fortified juices alone. Take at least two hours before or six hours after taking antacids containing magnesium or aluminum, or iron/zinc supplements.

Mechanism of Action

Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.

Pharmacokinetics

Onset

Within 30-60 minutes

Excretion

Primarily excreted renally (50-70% as unchanged drug) and to a lesser extent via the fecal route.

Half life

Approximately 3-5 hours

Absorption

Rapidly and well absorbed from the gastrointestinal tract; bioavailability is approximately 70-80%.

Metabolism

Limited hepatic metabolism; primarily forms four active metabolites (desethyleneciprofloxacin, sulfociprofloxacin, oxociprofloxacin, and formylciprofloxacin).

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or other quinolones
Concomitant administration with tizanidine
History of tendinopathy associated with quinolone use

Drug Interactions

NSAIDs

Increased risk of CNS stimulation and convulsions (rare).

Warfarin

Enhanced anticoagulant effect, increased bleeding risk.

Tizanidine

Increased risk of hypotension and somnolence.

Theophylline

Increased plasma levels of theophylline, leading to toxicity.

Antacids (Mg/Al), Iron/Zinc supplements

Decreased absorption of ciprofloxacin. Separate administration by at least 2-6 hours.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Overdose symptoms may include dizziness, tremor, headache, tiredness, seizures, abdominal pain, renal impairment, and crystalluria. Treatment involves gastric lavage, emesis, activated charcoal, and supportive care. Hemodialysis or peritoneal dialysis is not very effective.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted into breast milk. Discontinue nursing or the drug, taking into account the importance of the drug to the mother.

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or other quinolones
Concomitant administration with tizanidine
History of tendinopathy associated with quinolone use

Drug Interactions

NSAIDs

Increased risk of CNS stimulation and convulsions (rare).

Warfarin

Enhanced anticoagulant effect, increased bleeding risk.

Tizanidine

Increased risk of hypotension and somnolence.

Theophylline

Increased plasma levels of theophylline, leading to toxicity.

Antacids (Mg/Al), Iron/Zinc supplements

Decreased absorption of ciprofloxacin. Separate administration by at least 2-6 hours.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 10 tablets3 x 10 tablets

Shelf Life

24-36 months

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by regulatory authorities worldwide (e.g., FDA, DGDA)

Patent Status

Generic available, original patent expired

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied in numerous clinical trials for its efficacy in treating various bacterial infections. Post-marketing surveillance continues to monitor safety and rare adverse events.

Lab Monitoring

Renal function tests (for prolonged therapy or in elderly/impaired patients)
Liver function tests (periodically)
Blood counts (periodically)

Doctor Notes

Counsel patients on the black box warnings (tendinitis, tendon rupture, peripheral neuropathy, CNS effects).
Advise against co-administration with tizanidine and ensure proper spacing with multivalent cations.
Emphasize completing the full course.

Patient Guidelines

Complete the full course of treatment even if symptoms improve.
Stay well-hydrated to prevent crystalluria.
Avoid excessive sun exposure.
Report any tendon pain or swelling immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

May cause dizziness or lightheadedness, affecting the ability to drive or operate machinery. Exercise caution until you know how the medicine affects you.