Purisal
Generic Name
Purisal 0.31 mg Solution for Nebulization
Manufacturer
PharmaCorp Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| purisal 031 mg respirator solution | ৳ 10.00 | N/A |
Description
Overview of the medicine
Purisal 0.31 mg Respirator Solution is a selective beta-2 adrenergic agonist indicated for the relief of bronchospasm in conditions like asthma and COPD. It works by relaxing the smooth muscles in the airways, making breathing easier.
Uses & Indications
Dosage
Adults
0.31 mg by nebulization, 3-4 times daily as needed.
Elderly
Same as adult dose, but monitor for side effects.
Renal_impairment
No specific dose adjustment required, but use with caution.
How to Take
For oral inhalation only via a suitable nebulizer. The solution should not be swallowed. Patients should be instructed on the proper use and maintenance of the nebulizer.
Mechanism of Action
Purisal selectively stimulates beta-2 adrenergic receptors in the bronchial smooth muscle, leading to relaxation of these muscles, bronchodilation, and improved airflow. This action is mediated by an increase in intracellular cyclic AMP (cAMP) levels.
Pharmacokinetics
Onset
5-15 minutes
Excretion
Excreted primarily via the kidneys (urine) as metabolites and unchanged drug.
Half life
3-6 hours
Absorption
Rapidly absorbed from the respiratory tract after inhalation.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Purisal or any of its excipients
- Severe cardiac conditions with acute myocardial infarction
Drug Interactions
Beta-blockers
May reduce the bronchodilatory effect of Purisal and cause severe bronchospasm in asthmatic patients.
MAOIs and TCAs
May potentiate the vascular effects of Purisal, increasing the risk of cardiovascular side effects.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include excessive bronchodilation, tachycardia, tremor, headache, and hypokalemia. Treatment is symptomatic and supportive, typically involving discontinuation of the drug and monitoring of vital signs and serum potassium levels.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when Purisal is administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Purisal or any of its excipients
- Severe cardiac conditions with acute myocardial infarction
Drug Interactions
Beta-blockers
May reduce the bronchodilatory effect of Purisal and cause severe bronchospasm in asthmatic patients.
MAOIs and TCAs
May potentiate the vascular effects of Purisal, increasing the risk of cardiovascular side effects.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include excessive bronchodilation, tachycardia, tremor, headache, and hypokalemia. Treatment is symptomatic and supportive, typically involving discontinuation of the drug and monitoring of vital signs and serum potassium levels.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when Purisal is administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies and Hospitals
Approval Status
Approved by DGDA
Patent Status
Patented
Clinical Trials
Clinical trials demonstrated significant improvements in FEV1 and symptom scores compared to placebo in patients with asthma and COPD. Studies also confirmed a favorable safety profile.
Lab Monitoring
- Monitor serum potassium levels, especially in patients receiving high doses or concomitant diuretic therapy.
- Monitor pulmonary function tests (FEV1, PEFR) to assess efficacy.
Doctor Notes
- Counsel patients on proper nebulizer technique.
- Monitor for signs of paradoxical bronchospasm.
- Caution in patients with cardiovascular disorders.
Patient Guidelines
- Use the nebulizer correctly as instructed by your doctor or pharmacist.
- Do not exceed the recommended dose.
- Seek immediate medical attention if breathing difficulties worsen or do not improve after use.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or tremor, which could impair the ability to drive or operate machinery. Exercise caution until you know how Purisal affects you.
Lifestyle Advice
- Avoid smoking and exposure to environmental pollutants.
- Maintain good hydration.
- Regular exercise as tolerated.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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