Purisal
Generic Name
Purisal 0.63 mg Respirator Solution
Manufacturer
Alpha Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| purisal 063 mg respirator solution | ৳ 15.00 | N/A |
Description
Overview of the medicine
Purisal 0.63 mg Respirator Solution is an anti-inflammatory medication used to manage and prevent symptoms of asthma and chronic obstructive pulmonary disease (COPD). It is administered via nebulizer for direct delivery to the lungs.
Uses & Indications
Dosage
Adults
One unit dose (0.63 mg) twice daily via nebulizer, typically morning and evening. Dosage may be adjusted based on clinical response.
Elderly
No specific dose adjustment required, but monitor for side effects.
Renal_impairment
No specific dose adjustment required.
How to Take
For inhalation only. Administer using a jet nebulizer connected to an air compressor, with a suitable face mask or mouthpiece. Do not inject or swallow. Read the patient leaflet for full instructions.
Mechanism of Action
Purisal acts as a potent anti-inflammatory agent, reducing swelling and irritation in the airways. It decreases the frequency and severity of asthma and COPD exacerbations by suppressing the immune response in the lungs.
Pharmacokinetics
Onset
Therapeutic effects may begin within 24 hours, full effect in 1-2 weeks.
Excretion
Mainly via bile and feces; some renal excretion.
Half life
Approximately 3-5 hours (systemic), longer local effect.
Absorption
Minimal systemic absorption; primarily acts locally in the lungs.
Metabolism
Extensively metabolized by cytochrome P450 enzymes in the liver (e.g., CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Purisal or any component of the formulation
- Primary treatment of status asthmaticus or other acute episodes of asthma/COPD requiring intensive measures
Drug Interactions
Other corticosteroids
Increased risk of systemic corticosteroid effects.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
May increase systemic exposure to Purisal, potentially leading to increased side effects.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely to require treatment. Chronic overdose may lead to systemic corticosteroid effects (e.g., Cushing's syndrome). Symptomatic and supportive treatment.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Consult a doctor. Caution advised during lactation; weigh benefits against risks.
Side Effects
Contraindications
- Hypersensitivity to Purisal or any component of the formulation
- Primary treatment of status asthmaticus or other acute episodes of asthma/COPD requiring intensive measures
Drug Interactions
Other corticosteroids
Increased risk of systemic corticosteroid effects.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
May increase systemic exposure to Purisal, potentially leading to increased side effects.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely to require treatment. Chronic overdose may lead to systemic corticosteroid effects (e.g., Cushing's syndrome). Symptomatic and supportive treatment.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Consult a doctor. Caution advised during lactation; weigh benefits against risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Clinical trials showed Purisal to be effective in reducing asthma exacerbations and improving lung function in patients with moderate to severe asthma and COPD. Studies demonstrated a favorable safety profile.
Lab Monitoring
- Regular monitoring of pulmonary function tests (e.g., FEV1)
- Growth monitoring in pediatric patients
- Bone mineral density (long-term use)
Doctor Notes
- Educate patients on proper nebulizer technique.
- Emphasize daily, consistent use for maximal benefit.
- Regularly assess patient adherence and symptoms.
Patient Guidelines
- Rinse your mouth with water after each use to prevent oral candidiasis.
- Do not use for acute asthma attacks; use a fast-acting rescue inhaler.
- Follow your doctor's instructions carefully regarding dosage and administration.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Purisal is generally not expected to affect the ability to drive or operate machinery. However, if you experience side effects like dizziness or blurred vision, avoid these activities.
Lifestyle Advice
- Avoid smoking and exposure to respiratory irritants.
- Maintain good oral hygiene.
- Regular exercise and a healthy diet can support lung health.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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