Medicine Information

Purisal

Name: Purisal
Brand: Purisal
Rating: 4.5 (117 reviews)

Tablet1 mgAntihistamineATC: R06AX99

Generic Name

Purisaline 1 mg Tablet

Manufacturer

MediCo Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
purisal 1 mg tablet	৳ 1.00	৳ 10.00

Description

Overview of the medicine

Purisal 1 mg Tablet is an antihistamine used to relieve symptoms of allergies such as sneezing, runny nose, watery eyes, and itching. It works by blocking histamine, a natural substance that the body produces during an allergic reaction.

Uses & Indications

Seasonal allergic rhinitis

Perennial allergic rhinitis

Chronic idiopathic urticaria

Dosage

Adults

1 mg once daily, preferably in the evening.

Elderly

No dose adjustment usually required, but caution is advised in patients with renal impairment.

Renal_impairment

Dosage adjustment may be necessary based on creatinine clearance. For CrCl < 30 mL/min, 1 mg every other day.

How to Take

Take orally with or without food. Do not crush or chew the tablet.

Mechanism of Action

Purisaline, the active ingredient, is a potent H1-receptor antagonist. It selectively blocks peripheral H1-histamine receptors, thereby inhibiting the effects of histamine and alleviating allergic symptoms.

Pharmacokinetics

Onset

Within 30-60 minutes

Excretion

Mainly excreted via urine as metabolites, with a small portion eliminated unchanged in feces.

Half life

Approximately 12-15 hours

Absorption

Rapidly absorbed after oral administration, peak plasma concentration reached within 1-2 hours.

Metabolism

Extensively metabolized in the liver, primarily via cytochrome P450 enzymes.

Side Effects

Contraindications

Hypersensitivity to purisaline or any component of the tablet.
Severe renal impairment (CrCl < 10 mL/min).

Drug Interactions

CNS Depressants

Increased sedative effects when co-administered with alcohol or other CNS depressants.

CYP3A4 Inhibitors

Coadministration with strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase purisaline plasma levels.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms include drowsiness, tachycardia, and headache. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if recent ingestion.

Pregnancy & Lactation

Pregnancy Category B. Use only if clearly needed. Not recommended during breastfeeding as it may pass into breast milk.

Side Effects

Contraindications

Hypersensitivity to purisaline or any component of the tablet.
Severe renal impairment (CrCl < 10 mL/min).

Drug Interactions

CNS Depressants

Increased sedative effects when co-administered with alcohol or other CNS depressants.

CYP3A4 Inhibitors

Coadministration with strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase purisaline plasma levels.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms include drowsiness, tachycardia, and headache. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if recent ingestion.

Pregnancy & Lactation

Pregnancy Category B. Use only if clearly needed. Not recommended during breastfeeding as it may pass into breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 Tablets30 Tablets

Shelf Life

24 months from manufacturing date.

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Patent expired

Clinical Trials

Studies have shown Purisaline to be effective in reducing allergic symptoms with a generally well-tolerated safety profile.

Lab Monitoring

No routine lab monitoring required.
Renal function tests may be considered in patients with pre-existing renal impairment.

Doctor Notes

Advise patients on potential for drowsiness and caution regarding driving/operating machinery.
Review renal function in elderly or renally impaired patients before initiation.

Patient Guidelines

Take as directed by your doctor.
Do not exceed the recommended dose.
Avoid alcohol while taking this medicine, as it may increase drowsiness.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.