Ranzith
Generic Name
Ranzith
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ranzith 500 mg tablet | ৳ 42.00 | ৳ 168.00 |
| ranzith 250 mg capsule | ৳ 27.00 | ৳ 162.00 |
| ranzith 200 mg suspension | ৳ 85.26 | N/A |
Description
Overview of the medicine
Ranzith (Azithromycin) is a macrolide antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
500 mg once daily for 3 days OR 500 mg on Day 1, then 250 mg once daily for 4 days for respiratory/skin infections. For Chlamydia: 1g single dose.
Elderly
No dosage adjustment needed, but monitor for QT prolongation.
Renal_impairment
No dosage adjustment necessary for mild to moderate impairment (CrCl >10 mL/min). Exercise caution in severe impairment.
How to Take
Take orally, with or without food. Taking with food may decrease gastrointestinal upset.
Mechanism of Action
Azithromycin binds to the 50S ribosomal subunit of susceptible microorganisms, thereby inhibiting protein synthesis. This results in bacteriostatic effects, though it can be bactericidal at higher concentrations or against highly susceptible organisms.
Pharmacokinetics
Onset
Clinical effects typically observed within 2-3 days.
Excretion
Primarily excreted unchanged in bile; a small amount is excreted in urine.
Half life
Terminal elimination half-life is 2-4 days.
Absorption
Rapidly absorbed from the gastrointestinal tract, but bioavailability is approximately 37% due to extensive tissue distribution.
Metabolism
Primarily metabolized in the liver, but extensive metabolism does not significantly reduce serum concentration.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Warfarin
Increased anticoagulant effect; monitor INR.
Nelfinavir
Increased azithromycin serum concentrations; no dosage adjustment necessary for azithromycin, but monitor for side effects.
Antacids (aluminum and magnesium-containing)
May reduce peak serum levels of azithromycin. Administer azithromycin at least 1 hour before or 2 hours after antacids.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management is symptomatic and supportive. Gastric lavage and supportive measures are indicated.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Warfarin
Increased anticoagulant effect; monitor INR.
Nelfinavir
Increased azithromycin serum concentrations; no dosage adjustment necessary for azithromycin, but monitor for side effects.
Antacids (aluminum and magnesium-containing)
May reduce peak serum levels of azithromycin. Administer azithromycin at least 1 hour before or 2 hours after antacids.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management is symptomatic and supportive. Gastric lavage and supportive measures are indicated.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA/FDA
Patent Status
Off-patent (generic available)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established Azithromycin's efficacy and safety across various bacterial infections. Ongoing research explores its anti-inflammatory properties and role in chronic conditions.
Lab Monitoring
- Liver function tests (LFTs) if hepatic dysfunction is suspected.
- Renal function tests in patients with severe renal impairment.
- ECG monitoring in patients at risk for QT prolongation.
Doctor Notes
- Consider alternative antibiotics for severe infections requiring immediate broad-spectrum coverage.
- Advise patients about potential for C. difficile infection symptoms post-treatment.
- Carefully assess patients with prolonged QT interval risk factors.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Do not share this medication with others.
- Contact your doctor if you experience severe diarrhea, especially if it's watery or bloody.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness; caution advised when driving or operating machinery.
Lifestyle Advice
- Ensure adequate hydration while on antibiotics.
- Rest sufficiently to aid recovery from infection.
- Avoid alcohol consumption during treatment, as it may worsen side effects.
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Global Brand Names
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