Reset
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reset 120 mg suspension | ৳ 35.00 | N/A |
Description
Overview of the medicine
Reset 120 mg Suspension is an oral liquid medication containing Paracetamol (Acetaminophen), primarily used for reducing fever and relieving mild to moderate pain in children. It works by blocking certain chemical messengers in the brain that cause pain and fever.
Uses & Indications
Dosage
Adults
Not typically for adults in 120 mg suspension. Adults usually take 500 mg or 665 mg tablets.
Elderly
Not typically for elderly in 120 mg suspension.
Renal_impairment
Dosage adjustment may be required; consult a physician. Extended dosing interval is often recommended.
How to Take
For oral administration. Shake the bottle well before use. Use the provided measuring cup or spoon to ensure accurate dosing. Typically given every 4-6 hours as needed, not exceeding 4 doses in 24 hours. Dosage for children is usually 10-15 mg/kg per dose.
Mechanism of Action
Paracetamol is thought to act primarily in the central nervous system, inhibiting prostaglandin synthesis (COX-1 and COX-2) in the brain and spinal cord, which results in antipyretic and analgesic effects. It has weak anti-inflammatory effects.
Pharmacokinetics
Onset
Analgesia: 15-30 minutes; Antipyresis: <1 hour.
Excretion
Mainly excreted in urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1.25 to 3 hours (normal hepatic function), may be prolonged in liver disease.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract; peak plasma concentrations reached in 30-60 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation. A small portion is metabolized by cytochrome P450 into a toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by conjugation with glutathione.
Side Effects
Contraindications
- Known hypersensitivity to Paracetamol or any component of the suspension
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Chronic alcohol consumption increases the risk of liver damage.
Warfarin
May increase the anticoagulant effect of warfarin, requiring monitoring of INR.
Cholestyramine
Reduces paracetamol absorption.
Carbamazepine, Phenytoin, Rifampicin
May increase the risk of hepatotoxicity due to enzyme induction.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze.
Overdose
Overdose can cause severe liver damage, which may be fatal. Symptoms include nausea, vomiting, abdominal pain, loss of appetite, and jaundice. Seek immediate medical attention. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Considered safe for use during pregnancy and breastfeeding at recommended doses. It is the preferred analgesic/antipyretic during these periods. However, always consult a healthcare professional.
Side Effects
Contraindications
- Known hypersensitivity to Paracetamol or any component of the suspension
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Chronic alcohol consumption increases the risk of liver damage.
Warfarin
May increase the anticoagulant effect of warfarin, requiring monitoring of INR.
Cholestyramine
Reduces paracetamol absorption.
Carbamazepine, Phenytoin, Rifampicin
May increase the risk of hepatotoxicity due to enzyme induction.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze.
Overdose
Overdose can cause severe liver damage, which may be fatal. Symptoms include nausea, vomiting, abdominal pain, loss of appetite, and jaundice. Seek immediate medical attention. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Considered safe for use during pregnancy and breastfeeding at recommended doses. It is the preferred analgesic/antipyretic during these periods. However, always consult a healthcare professional.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture. Check the expiry date on the packaging.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved by health authorities worldwide (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied and widely used for decades. Numerous clinical trials have confirmed its efficacy and safety for pain and fever management, particularly in pediatric populations.
Lab Monitoring
- Liver function tests (in cases of prolonged use, high doses, or suspected overdose)
- Renal function tests (in prolonged use or pre-existing renal impairment)
Doctor Notes
- Advise parents on correct weight-based dosing for pediatric patients.
- Emphasize the risk of hepatotoxicity with overdose; educate on maximum daily doses and avoiding concomitant paracetamol products.
- Counsel on recognizing signs of liver injury.
Patient Guidelines
- Do not exceed the recommended dose.
- Do not take with other paracetamol-containing products.
- Consult a doctor if fever persists for more than 3 days or pain for more than 5 days.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Generally, Paracetamol does not impair the ability to drive or operate machinery. However, if you experience dizziness or drowsiness, avoid these activities.
Lifestyle Advice
- Ensure adequate hydration, especially when experiencing fever.
- Get sufficient rest to aid recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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