Reset
Generic Name
Paracetamol
Manufacturer
Example Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reset 80 mg pediatric drop | ৳ 30.00 | N/A |
Description
Overview of the medicine
Reset 80 mg Pediatric Drop is used for the symptomatic relief of mild to moderate pain and fever in infants and young children.
Uses & Indications
Dosage
Adults
For infants 3-12 months: 0.5 mL (40 mg) to 1.0 mL (80 mg) every 4-6 hours as needed. Maximum 4 doses in 24 hours. Dosage is typically 10-15 mg/kg per dose. Consult physician or pharmacist for exact dosage based on child's weight.
Elderly
Not applicable for pediatric drops. Elderly patients should use appropriate adult formulations.
Renal_impairment
Dosage adjustment may be required; consult a physician.
How to Take
Oral administration. Use the provided dropper for accurate dosing. Can be given directly or mixed with a small amount of water or juice.
Mechanism of Action
Paracetamol primarily inhibits prostaglandin synthesis in the central nervous system, leading to its analgesic and antipyretic effects. It has weak anti-inflammatory properties.
Pharmacokinetics
Onset
30-60 minutes for analgesia, 30 minutes for antipyresis.
Excretion
Excreted mainly in the urine as glucuronide and sulfate conjugates, with less than 5% excreted unchanged.
Half life
1.5-3 hours in healthy adults; slightly longer in neonates and with hepatic impairment.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation, and a small amount via cytochrome P450 pathway (producing a toxic metabolite, NAPQI, detoxified by glutathione).
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment
Drug Interactions
Alcohol
Increases risk of hepatotoxicity, especially with chronic excessive use.
Warfarin
May enhance anticoagulant effect with prolonged use, increasing risk of bleeding.
Storage
Store below 30°C, protected from light and moisture. Do not freeze.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and eventually hepatic necrosis. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment
Drug Interactions
Alcohol
Increases risk of hepatotoxicity, especially with chronic excessive use.
Warfarin
May enhance anticoagulant effect with prolonged use, increasing risk of bleeding.
Storage
Store below 30°C, protected from light and moisture. Do not freeze.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and eventually hepatic necrosis. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, refer to package label.
Availability
Pharmacies, drugstores
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied and widely used for decades. Ongoing research focuses on specific populations or new formulations.
Lab Monitoring
- Liver function tests (in case of prolonged use or overdose)
- Renal function tests (in case of prolonged use or overdose)
Doctor Notes
- Emphasize accurate dosing for pediatric patients using the provided dropper.
- Counsel parents on the importance of not exceeding the maximum daily dose to prevent hepatotoxicity.
Patient Guidelines
- Always use the provided dropper for accurate measurement.
- Do not exceed the recommended dose.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, administer it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
Paracetamol is not known to impair the ability to drive or operate machinery.
Lifestyle Advice
- Ensure adequate hydration, especially when feverish.
- Avoid giving other paracetamol-containing products simultaneously.
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