Ritch
Generic Name
Etoricoxib
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ritch 120 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Ritch 120 mg Tablet contains Etoricoxib, a selective cyclooxygenase-2 (COX-2) inhibitor used to relieve pain and inflammation in various conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gout.
Uses & Indications
Dosage
Adults
Acute gouty arthritis: 120 mg once daily for a maximum of 8 days. Acute pain/dysmenorrhea: 120 mg once daily for a maximum of 8 days (for short-term use).
Elderly
No specific dose adjustment is generally required, but caution is advised due to potential age-related decrease in renal function and increased risk of adverse effects.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Not recommended for severe renal impairment (creatinine clearance <30 mL/min).
How to Take
Take orally with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2), an enzyme responsible for the synthesis of prostaglandins, which are mediators of pain and inflammation. By inhibiting COX-2, it reduces prostaglandin production, thereby alleviating pain and inflammation.
Pharmacokinetics
Onset
Pain relief usually within 24 minutes to an hour.
Excretion
Mainly through urine (approx 70%) and feces (approx 30%) as metabolites.
Half life
Approximately 22 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached in approximately 1 hour.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (mainly CYP3A4) to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to Etoricoxib or any component of the tablet
- •Active peptic ulceration or gastrointestinal bleeding
- •Severe hepatic dysfunction
- •Severe uncontrolled hypertension
- •Congestive heart failure (NYHA II-IV)
- •Established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
- •Known history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased prothrombin time/INR. Monitor closely.
Methotrexate
Increased plasma methotrexate concentrations.
Oral contraceptives
Increased exposure to ethinyl estradiol.
Cyclosporine, Tacrolimus
Increased nephrotoxicity.
Diuretics, ACE inhibitors, Angiotensin II Antagonists
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal disturbances (e.g., nausea, vomiting, stomach pain), drowsiness. In case of overdose, seek immediate medical attention. Management is supportive and symptomatic.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the third trimester due to potential risks to the fetus (e.g., premature closure of ductus arteriosus). Avoid during lactation as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, EMA, DGDA)
Patent Status
Generically available
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
