Take the tablet orally with food or milk to minimize gastrointestinal discomfort. Do not crush or chew the tablet. Swallow whole with a glass of water.

Roxacene acts by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever. By reducing prostaglandin synthesis, Roxacene exerts its analgesic, anti-inflammatory, and antipyretic effects.

• •Known hypersensitivity to Roxacene, aspirin, or other NSAIDs.
• •History of gastrointestinal bleeding or peptic ulcer disease.
• •Severe heart failure (NYHA Class III-IV).
• •Severe renal or hepatic impairment.
• •Third trimester of pregnancy.
• •Coronary artery bypass graft (CABG) surgery.

Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.

Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, lethargy, and gastrointestinal bleeding. In rare cases, hypertension, acute renal failure, respiratory depression, and coma may occur. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered within the first hour of ingestion.

Pregnancy Category C (first and second trimesters); avoid in third trimester (Category D due to risk of premature closure of ductus arteriosus). Use during lactation only if the potential benefit justifies the potential risk to the infant, as NSAIDs can pass into breast milk.