Roxagen
Generic Name
Roxagen 20 mg Tablet
Manufacturer
Pharmatek Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| roxagen 20 mg tablet | ৳ 180.00 | ৳ 540.00 |
Description
Overview of the medicine
Roxagen 20 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness from conditions like arthritis. It works by blocking certain natural substances in the body that cause inflammation and pain.
Uses & Indications
Dosage
Adults
Usually 20 mg once daily, or 10 mg twice daily. Maximum daily dose is 20 mg.
Elderly
Lower doses may be considered; start with 10 mg once daily.
Renal_impairment
Caution advised; dose reduction may be necessary in severe impairment. Not recommended if creatinine clearance is <30 mL/min.
How to Take
Take Roxagen 20 mg Tablet orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Roxagen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins mediate inflammation, pain, and fever, so by inhibiting their synthesis, Roxagen exerts its anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Pain relief within 1 hour, anti-inflammatory effects develop over several days.
Excretion
Excreted almost equally in urine and feces, mainly as inactive metabolites.
Half life
Approximately 30-86 hours (average 50 hours), allowing once-daily dosing.
Absorption
Well absorbed from the gastrointestinal tract; peak plasma concentrations achieved in 3-5 hours.
Metabolism
Extensively metabolized in the liver by hydroxylation and conjugation; primarily by CYP2C9.
Side Effects
Contraindications
- •Hypersensitivity to Roxagen or other NSAIDs
- •Active gastrointestinal bleeding or peptic ulcer disease
- •Severe renal or hepatic impairment
- •Severe heart failure
- •Third trimester of pregnancy
- •Aspirin-induced asthma, urticaria, or allergic-type reactions
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
ACE Inhibitors/ARBs
Reduced antihypertensive effect, increased risk of renal impairment.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is symptomatic and supportive, including gastric lavage or activated charcoal if recent ingestion. Monitor renal and hepatic function.
Pregnancy & Lactation
Pregnancy Category C in early pregnancy, Category D in the third trimester (due to risk of premature closure of fetal ductus arteriosus). Avoid use in the third trimester. Use with caution during lactation; small amounts may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Expired
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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