Roxagen 70 mg Tablet should be taken orally, with or without food. It is recommended to take it with food or milk if stomach upset occurs. Swallow the tablet whole with a glass of water, do not crush or chew.

Roxagen selectively inhibits cyclooxygenase-2 (COX-2), an enzyme responsible for the synthesis of prostaglandins involved in inflammation, pain, and fever. By inhibiting COX-2, it reduces the production of these inflammatory mediators, thereby exerting its analgesic, anti-inflammatory, and antipyretic effects.

• •Hypersensitivity to Roxagen, sulfonamides, or any components of the formulation
• •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
• •Active gastrointestinal bleeding or peptic ulceration
• •Severe heart failure (NYHA Class III-IV)
• •Severe renal impairment (CrCl < 30 mL/min) or severe hepatic impairment
• •Third trimester of pregnancy

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms of NSAID overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is primarily supportive and symptomatic. Gastric lavage and/or activated charcoal may be considered within 4 hours of ingestion.

Pregnancy: Use of NSAIDs, including Roxagen, during the third trimester of pregnancy is contraindicated due to the risk of premature closure of the fetal ductus arteriosus. Use during other trimesters only if the potential benefit justifies the potential risk to the fetus. Lactation: Roxagen is excreted in breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.