Roxagen tablets should be taken orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water, do not chew or crush.

Roxagen works by inhibiting the activity of cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins, mediators of pain, inflammation, and fever.

• •Hypersensitivity to Roxagen or any other NSAID, including aspirin
• •Active gastrointestinal bleeding or peptic ulcer disease
• •Severe renal or hepatic impairment
• •Severe heart failure
• •Third trimester of pregnancy
• •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive treatment. Gastric lavage or activated charcoal may be considered within the first hour of ingestion.

Pregnancy: Avoid in the third trimester due to potential adverse effects on fetal cardiovascular system. Use with caution in the first and second trimesters only if clearly needed. Lactation: NSAIDs are generally not recommended during breastfeeding due to potential excretion in breast milk.