Roxim
Generic Name
Cefuroxime Axetil
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| roxim 100 mg suspension | ৳ 145.00 | N/A |
Description
Overview of the medicine
Cefuroxime Axetil is a broad-spectrum cephalosporin antibiotic used to treat a wide range of bacterial infections. The 100 mg suspension is primarily formulated for pediatric use.
Uses & Indications
Dosage
Adults
Generally, 250 mg to 500 mg twice daily, depending on the infection. For suspension, dosage is typically for pediatric use.
Elderly
Similar to adult dosage, but dose adjustment may be necessary in case of renal impairment.
Renal_impairment
Dosage interval should be prolonged or dose reduced in patients with significant renal impairment (creatinine clearance < 30 mL/min).
How to Take
Take orally with food for optimum absorption. Shake the bottle well before each use. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Cefuroxime Axetil is a prodrug that is hydrolyzed to cefuroxime. Cefuroxime is a bactericidal agent that works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations are usually achieved 2-3 hours after administration with food.
Excretion
Mainly excreted unchanged in the urine by both glomerular filtration and tubular secretion. Approximately 50% of the dose is excreted within 12 hours.
Half life
Approximately 1 to 1.5 hours in healthy adults.
Absorption
Rapidly absorbed from the gastrointestinal tract after oral administration and rapidly hydrolyzed to cefuroxime. Absorption is enhanced when taken with food.
Metabolism
Cefuroxime axetil is extensively hydrolyzed by esterases in the intestinal mucosa and blood to its active form, cefuroxime. Cefuroxime itself is not metabolized.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime or to any of the excipients.
- Known hypersensitivity to cephalosporin antibiotics.
- History of severe hypersensitivity (e.g., anaphylactic reaction) to any other type of beta-lactam antibacterial agent (e.g., penicillins, monobactams and carbapenems).
Drug Interactions
Probenecid
Concomitant administration of probenecid increases the AUC of cefuroxime by about 50%, prolonging its elimination.
Oral Anticoagulants
May increase INR in patients taking oral anticoagulants. Monitor INR closely.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; advise additional contraceptive methods.
Antacids/H2-receptor antagonists
May decrease the bioavailability of cefuroxime axetil, potentially reducing its effectiveness. Administer at least 2 hours apart.
Storage
Store the dry powder below 30°C, protected from light and moisture. Keep the reconstituted suspension in a refrigerator (2-8°C) and discard after 7 days.
Overdose
Overdosage can lead to neurological sequelae including convulsions. Management is primarily symptomatic and supportive. Hemodialysis and peritoneal dialysis may be helpful in removing cefuroxime.
Pregnancy & Lactation
Pregnancy Category B. While animal studies have not shown harm, adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Cefuroxime is excreted in small amounts in breast milk; caution is advised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime or to any of the excipients.
- Known hypersensitivity to cephalosporin antibiotics.
- History of severe hypersensitivity (e.g., anaphylactic reaction) to any other type of beta-lactam antibacterial agent (e.g., penicillins, monobactams and carbapenems).
Drug Interactions
Probenecid
Concomitant administration of probenecid increases the AUC of cefuroxime by about 50%, prolonging its elimination.
Oral Anticoagulants
May increase INR in patients taking oral anticoagulants. Monitor INR closely.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; advise additional contraceptive methods.
Antacids/H2-receptor antagonists
May decrease the bioavailability of cefuroxime axetil, potentially reducing its effectiveness. Administer at least 2 hours apart.
Storage
Store the dry powder below 30°C, protected from light and moisture. Keep the reconstituted suspension in a refrigerator (2-8°C) and discard after 7 days.
Overdose
Overdosage can lead to neurological sequelae including convulsions. Management is primarily symptomatic and supportive. Hemodialysis and peritoneal dialysis may be helpful in removing cefuroxime.
Pregnancy & Lactation
Pregnancy Category B. While animal studies have not shown harm, adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Cefuroxime is excreted in small amounts in breast milk; caution is advised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted powder: 2 years from manufacturing date. Reconstituted suspension: 7 days when stored in a refrigerator (2-8°C).
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of Cefuroxime Axetil in treating various bacterial infections across different age groups, especially in pediatric populations.
Lab Monitoring
- Periodic assessment of renal and hepatic function is advisable during prolonged therapy.
- Monitor complete blood count (CBC) in patients receiving prolonged treatment.
Doctor Notes
- Always inquire about patient's penicillin allergy history due to potential cross-reactivity with cephalosporins.
- Emphasize the importance of completing the full course of antibiotics to prevent resistance.
- Advise parents on proper measurement and administration of the suspension for pediatric patients.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Take with food to enhance absorption and reduce gastrointestinal upset.
- Shake the suspension well before each use.
- Do not save unused medication for future infections.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness, which could impair your ability to drive or operate machinery. Exercise caution until you know how the medicine affects you.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid alcohol consumption during treatment as it may exacerbate side effects.
- Inform your doctor about any persistent or severe side effects.
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