Roxim
Generic Name
Cefixime
Manufacturer
UniMed & UniHealth
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| roxim 400 mg capsule | ৳ 55.00 | ৳ 550.00 |
Description
Overview of the medicine
Cefixime is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections including those of the respiratory tract, urinary tract, and skin.
Uses & Indications
Dosage
Adults
400 mg once daily or 200 mg twice daily, depending on the infection. Duration varies from 7 to 14 days.
Elderly
Similar to adults, but dose adjustment may be required in patients with significant renal impairment.
Renal_impairment
For creatinine clearance < 60 mL/min, dose adjustment is required (e.g., 200 mg once daily).
How to Take
Take orally, with or without food. To ensure full absorption, it can be taken at the same time each day.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Varies with the type and severity of infection.
Excretion
Primarily excreted via the kidneys (about 50-60% as unchanged drug) and biliary excretion.
Half life
Plasma half-life of about 3-4 hours.
Absorption
Approximately 40-50% absorbed orally. Food may delay but not significantly reduce absorption.
Metabolism
Not extensively metabolized in the body.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporin antibiotics.
- History of anaphylaxis to penicillin or other beta-lactam antibiotics.
Drug Interactions
Warfarin
May increase prothrombin time and INR; monitor coagulation parameters.
Nifedipine
May increase Cefixime plasma levels.
Carbamazepine
May increase carbamazepine plasma levels; monitor carbamazepine levels.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. Use with caution in nursing mothers as Cefixime is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporin antibiotics.
- History of anaphylaxis to penicillin or other beta-lactam antibiotics.
Drug Interactions
Warfarin
May increase prothrombin time and INR; monitor coagulation parameters.
Nifedipine
May increase Cefixime plasma levels.
Carbamazepine
May increase carbamazepine plasma levels; monitor carbamazepine levels.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. Use with caution in nursing mothers as Cefixime is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 24-36 months from the manufacturing date, consult the product packaging for exact details.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone numerous clinical trials to establish its efficacy and safety in various bacterial infections, confirming its role as a broad-spectrum antibiotic.
Lab Monitoring
- Renal function tests should be monitored in patients with pre-existing renal impairment or during prolonged high-dose therapy.
- Prothrombin time/INR should be monitored in patients concurrently taking anticoagulants.
Doctor Notes
- Prescribe based on susceptibility testing if feasible, especially in cases of recurrent infections.
- Advise patients on the risk of Clostridioides difficile infection and to seek medical attention if severe, persistent diarrhea occurs.
- Adjust dosage in patients with significant renal impairment.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve, to prevent recurrence and resistance.
- Report any severe or persistent diarrhea, as it could be a sign of a more serious condition.
- Inform your doctor about any known allergies, especially to penicillin or other antibiotics.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness. Use caution if operating machinery or driving until you know how Cefixime affects you.
Lifestyle Advice
- Maintain good hydration during treatment.
- Avoid alcohol if it exacerbates gastrointestinal side effects.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Roxim Brand
Other medicines available under the same brand name
