Roxim
Generic Name
Roxithromycin
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| roxim 25 mg pediatric drop | ৳ 85.00 | N/A |
Description
Overview of the medicine
Roxim 25 mg Pediatric Drop contains Roxithromycin, a macrolide antibiotic used to treat various bacterial infections in children. It works by inhibiting bacterial protein synthesis.
Uses & Indications
Dosage
Neonates
Not generally recommended for neonates unless specifically indicated and under strict medical supervision.
Infants_children
5-8 mg/kg body weight per day, given as a single dose or divided into two doses. Typically, for 25 mg/ml drop, this translates to specific drops per kg.
Renal_impairment
Dose adjustment may be necessary in severe renal impairment; consult physician.
How to Take
Administer orally, preferably before meals (at least 15 minutes before) for better absorption. Use the provided dropper for accurate dosing.
Mechanism of Action
Roxithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby interfering with translocation reactions and preventing the incorporation of amino acids into growing peptide chains. It is primarily bacteriostatic but can be bactericidal at high concentrations against certain organisms.
Pharmacokinetics
Onset
Varies by infection type and severity, typically within hours.
Excretion
Primarily excreted unchanged in feces (about 65%) and a smaller portion via urine (about 10%) and bile.
Half life
Approximately 10-12 hours in adults, longer in children.
Absorption
Rapidly but incompletely absorbed from the gastrointestinal tract; food may delay absorption. Bioavailability is about 50-60%.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Roxithromycin or any other macrolide antibiotic
- Co-administration with ergot alkaloids (e.g., ergotamine, dihydroergotamine)
- Co-administration with cisapride, pimozide, or terfenadine
Drug Interactions
Digoxin
May increase digoxin levels.
Warfarin
May increase anticoagulant effect, leading to bleeding.
Midazolam
May increase midazolam concentration and sedative effects.
Cyclosporine
May increase cyclosporine levels.
Theophylline
May increase theophylline levels.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal disturbances (nausea, vomiting, diarrhea) and possibly hearing loss (reversible). Treatment is symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Category B for pregnancy. Use only if clearly needed. Excreted into breast milk in small amounts; use with caution. Consult a physician.
Side Effects
Contraindications
- Hypersensitivity to Roxithromycin or any other macrolide antibiotic
- Co-administration with ergot alkaloids (e.g., ergotamine, dihydroergotamine)
- Co-administration with cisapride, pimozide, or terfenadine
Drug Interactions
Digoxin
May increase digoxin levels.
Warfarin
May increase anticoagulant effect, leading to bleeding.
Midazolam
May increase midazolam concentration and sedative effects.
Cyclosporine
May increase cyclosporine levels.
Theophylline
May increase theophylline levels.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal disturbances (nausea, vomiting, diarrhea) and possibly hearing loss (reversible). Treatment is symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Category B for pregnancy. Use only if clearly needed. Excreted into breast milk in small amounts; use with caution. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have established the efficacy and safety of Roxithromycin in pediatric bacterial infections, demonstrating comparable outcomes to other macrolides with a favorable tolerability profile.
Lab Monitoring
- Liver function tests (in patients with pre-existing hepatic impairment or prolonged therapy)
- Renal function tests (in patients with severe renal impairment)
- INR monitoring (for patients on warfarin)
Doctor Notes
- Emphasize adherence to the full prescribed course to prevent resistance.
- Advise parents on proper dropper use for accurate dosing.
- Monitor for signs of GI upset or allergic reactions, especially in young children.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Do not share this medication with others.
- Store in a cool, dry place away from light and moisture.
- Shake well before use for suspensions/drops.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Roxithromycin generally does not affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids.
- Ensure adequate rest.
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