Roxim
Generic Name
Cefuroxime Axetil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| roxim 200 mg capsule | ৳ 40.00 | ৳ 320.00 |
Description
Overview of the medicine
Roxim 200 mg capsule contains Cefuroxime Axetil, a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections including respiratory tract, urinary tract, skin and soft tissue infections, and otitis media.
Uses & Indications
Dosage
Adults
For most infections, 250-500 mg twice daily. For uncomplicated urinary tract infections, 125-250 mg twice daily. For pharyngitis/tonsillitis, 250 mg twice daily for 5-10 days. For acute bacterial sinusitis, 250-500 mg twice daily for 10 days.
Elderly
Similar to adult dosage, but dose adjustment may be necessary in case of severe renal impairment.
Renal_impairment
Creatinine clearance 10-29 mL/min: 250 mg once daily. Creatinine clearance <10 mL/min: 125 mg once daily.
How to Take
Administer orally with food to enhance absorption. Do not crush or chew the capsule; swallow whole.
Mechanism of Action
Cefuroxime Axetil is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), which prevents the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-3 hours after a meal.
Excretion
Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.
Half life
Approximately 1.2-1.5 hours in adults with normal renal function.
Absorption
Well absorbed from the gastrointestinal tract after oral administration, especially with food, and rapidly hydrolyzed to cefuroxime. Bioavailability is approximately 37-52%.
Metabolism
Cefuroxime Axetil is rapidly hydrolyzed in the intestinal mucosa and blood to release cefuroxime. Cefuroxime itself is not significantly metabolized.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams)
Drug Interactions
Probenecid
Increases cefuroxime concentrations and prolongs its half-life.
Oral contraceptives
May reduce the efficacy of oral contraceptives (rarely significant, but advice on additional contraception might be given).
Antacids/H2-receptor antagonists/Proton pump inhibitors
May decrease the bioavailability of cefuroxime axetil by reducing gastric acidity.
Storage
Store at room temperature (below 30°C), away from moisture and direct light. Keep out of reach of children.
Overdose
Overdose symptoms may include cerebral irritation leading to convulsions. Management includes supportive care, gastric lavage if ingestion is recent, and hemodialysis/peritoneal dialysis may be considered to remove the drug.
Pregnancy & Lactation
Pregnancy Category B. Cefuroxime crosses the placenta. Use in pregnancy only if clearly needed. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but caution is advised.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams)
Drug Interactions
Probenecid
Increases cefuroxime concentrations and prolongs its half-life.
Oral contraceptives
May reduce the efficacy of oral contraceptives (rarely significant, but advice on additional contraception might be given).
Antacids/H2-receptor antagonists/Proton pump inhibitors
May decrease the bioavailability of cefuroxime axetil by reducing gastric acidity.
Storage
Store at room temperature (below 30°C), away from moisture and direct light. Keep out of reach of children.
Overdose
Overdose symptoms may include cerebral irritation leading to convulsions. Management includes supportive care, gastric lavage if ingestion is recent, and hemodialysis/peritoneal dialysis may be considered to remove the drug.
Pregnancy & Lactation
Pregnancy Category B. Cefuroxime crosses the placenta. Use in pregnancy only if clearly needed. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of cefuroxime axetil across various bacterial infections in adults and pediatric patients.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with impaired renal function)
- Complete blood count (for prolonged therapy)
Doctor Notes
- Consider renal function in elderly patients and those with pre-existing kidney disease.
- Educate patients on the importance of completing the full course of therapy.
- Monitor for signs of hypersensitivity reactions, especially after the first dose.
Patient Guidelines
- Complete the full course of antibiotics, even if you feel better, to prevent recurrence and development of antibiotic resistance.
- Take this medicine with food.
- Inform your doctor if you develop severe or persistent diarrhea.
- Do not share this medication with others.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness. Patients should be advised to exercise caution when driving or operating machinery until they know how Roxim affects them.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Stay hydrated by drinking plenty of fluids.
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