Secrin
Generic Name
Enteroclinostat
Manufacturer
Innovate Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| secrin 1 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Secrin 1 mg Tablet is an oral medication containing Enteroclinostat, a selective enteric secretagogue inhibitor designed to manage symptoms of Irritable Bowel Syndrome with Diarrhea (IBS-D) in adults. It helps alleviate abdominal pain, bloating, and changes in bowel habits by normalizing fluid secretion in the gut.
Uses & Indications
Dosage
Adults
1 mg orally once daily, preferably before a meal.
Elderly
No specific dose adjustment required, but close monitoring is recommended.
Renal_impairment
Mild to moderate impairment: No dose adjustment. Severe impairment: Use with caution, consider reduced dose (e.g., 0.5 mg once daily).
How to Take
Take Secrin 1 mg Tablet orally with water, preferably 30 minutes before a meal to optimize absorption and efficacy. Do not crush, chew, or break the tablet.
Mechanism of Action
Enteroclinostat selectively inhibits specific receptors in the intestinal wall responsible for excessive fluid secretion and abnormal gut motility. By modulating these pathways, it helps restore the normal balance of fluid and electrolyte transport, thereby reducing diarrheal symptoms and improving gut comfort.
Pharmacokinetics
Onset
Within 2-4 hours for symptomatic relief.
Excretion
Excreted mainly through feces (approx. 70%) and urine (approx. 30%) as metabolites.
Half life
Approximately 6-8 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; however, systemic bioavailability is low due to extensive first-pass metabolism.
Metabolism
Primarily metabolized in the liver via CYP3A4 pathway.
Side Effects
Contraindications
- Hypersensitivity to Enteroclinostat or any component of the tablet
- Mechanical gastrointestinal obstruction
- Patients with severe liver impairment
Drug Interactions
CYP3A4 Inducers (e.g., Rifampicin, Carbamazepine)
May decrease plasma levels of Enteroclinostat, reducing efficacy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
May increase plasma levels of Enteroclinostat, potentially increasing side effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive measures should be initiated. There is no specific antidote for Enteroclinostat.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is unknown if Enteroclinostat is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to Enteroclinostat or any component of the tablet
- Mechanical gastrointestinal obstruction
- Patients with severe liver impairment
Drug Interactions
CYP3A4 Inducers (e.g., Rifampicin, Carbamazepine)
May decrease plasma levels of Enteroclinostat, reducing efficacy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
May increase plasma levels of Enteroclinostat, potentially increasing side effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive measures should be initiated. There is no specific antidote for Enteroclinostat.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is unknown if Enteroclinostat is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved (Hypothetical)
Patent Status
Under patent (Hypothetical)
Clinical Trials
Clinical trials demonstrated significant improvement in IBS-D symptoms compared to placebo, with a favorable safety profile. Further long-term studies are ongoing.
Lab Monitoring
- No routine lab monitoring required for healthy individuals. For patients with renal or hepatic impairment, monitor liver and kidney function tests periodically.
Doctor Notes
- Advise patients on lifestyle modifications to complement drug therapy.
- Monitor for potential drug interactions, especially with CYP3A4 modulators.
- Educate patients on proper administration and adherence to treatment.
Patient Guidelines
- Take the medication exactly as prescribed by your doctor.
- Do not stop taking Secrin without consulting your doctor, even if symptoms improve.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Secrin is generally not expected to impair the ability to drive or operate machinery. However, if you experience dizziness or fatigue, exercise caution.
Lifestyle Advice
- Maintain a balanced diet and stay well-hydrated.
- Avoid trigger foods that worsen IBS symptoms.
- Incorporate stress management techniques into your daily routine.
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