Secrin
Generic Name
Secrin
Manufacturer
Innovate Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| secrin 4 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Secrin 4 mg tablet contains a synthetic corticosteroid used for its potent anti-inflammatory and immunosuppressive properties. It is prescribed for various conditions including allergic disorders, dermatological diseases, rheumatic disorders, and certain respiratory conditions.
Uses & Indications
Dosage
Adults
Initial dose of 4-16 mg daily, adjusted according to response and nature of the disease. Maintenance dose usually 2-8 mg daily. Should be taken with food.
Elderly
Lower doses may be required due to increased sensitivity and potential for adverse effects. Careful monitoring is advised.
Renal_impairment
No specific dose adjustment required, but use with caution. Hepatic impairment may require dose adjustment.
How to Take
Administer orally, preferably with food or milk to minimize gastrointestinal irritation. Take as directed by the physician.
Mechanism of Action
Secrin works by binding to intracellular glucocorticoid receptors, forming a complex that translocates into the nucleus. This complex modulates gene expression, leading to the synthesis of anti-inflammatory proteins and inhibition of pro-inflammatory mediators. It also reduces immune cell activity.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within 1-2 hours, with full effect within 24 hours.
Excretion
Mainly excreted in urine as metabolites.
Half life
Biological half-life is approximately 18-36 hours, allowing once-daily dosing.
Absorption
Rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to Secrin or any component of the tablet
- Live virus vaccines (during immunosuppressive doses)
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding/ulceration.
Warfarin
Altered anticoagulant effect (monitor INR).
Diuretics (potassium-depleting)
Increased risk of hypokalemia.
Storage
Store in a cool, dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is generally not life-threatening. Chronic overdose can lead to severe side effects suchs as Cushing's syndrome, adrenal suppression, and electrolyte imbalances. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use only if the potential benefit justifies the potential risk to the fetus/infant. Corticosteroids can be excreted in breast milk. Consult a doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to Secrin or any component of the tablet
- Live virus vaccines (during immunosuppressive doses)
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding/ulceration.
Warfarin
Altered anticoagulant effect (monitor INR).
Diuretics (potassium-depleting)
Increased risk of hypokalemia.
Storage
Store in a cool, dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is generally not life-threatening. Chronic overdose can lead to severe side effects suchs as Cushing's syndrome, adrenal suppression, and electrolyte imbalances. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use only if the potential benefit justifies the potential risk to the fetus/infant. Corticosteroids can be excreted in breast milk. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Proprietary
Clinical Trials
Ongoing trials exploring its efficacy in refractory autoimmune conditions. Phase III trials completed for asthma management.
Lab Monitoring
- Blood pressure
- Blood glucose
- Electrolytes (especially potassium)
- Bone mineral density (long-term use)
- Ophthalmological exam (long-term use)
Doctor Notes
- Educate patients on the importance of gradual dose reduction.
- Monitor for signs of infection and metabolic disturbances.
- Consider bone protection strategies for long-term users.
Patient Guidelines
- Do not stop taking Secrin abruptly, especially after prolonged use, as this can lead to withdrawal symptoms.
- Report any unusual swelling, weight gain, or mood changes to your doctor.
- Avoid exposure to infections and consult your doctor if you develop fever or signs of infection.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Secrin generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Maintain a diet rich in calcium and vitamin D to support bone health.
- Engage in regular, moderate exercise if possible.
- Avoid smoking and excessive alcohol.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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