Sefril
Generic Name
Cefuroxime Axetil
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sefril 125 mg suspension | ৳ 95.00 | N/A |
Description
Overview of the medicine
Cefuroxime axetil is a broad-spectrum cephalosporin antibiotic used to treat various bacterial infections including respiratory tract infections, ear infections, skin and soft tissue infections, and urinary tract infections. It is effective against a wide range of gram-positive and gram-negative bacteria.
Uses & Indications
Dosage
Adults
The 125 mg suspension is primarily for pediatric use. For adults, generally 250-500 mg twice daily as tablets, depending on infection type and severity.
Elderly
No specific dose adjustment is required unless there is severe renal impairment. Refer to adult dosages.
Renal_impairment
Dosage adjustment is necessary for patients with significantly impaired renal function (creatinine clearance < 30 ml/min). For CrCl 10-29 ml/min: 125 mg every 24 hours. For CrCl < 10 ml/min: 125 mg every 48 hours.
Children_over_3_months
Most infections: 125 mg twice daily. Severe infections or otitis media: 250 mg twice daily. Maximum daily dose 500 mg.
How to Take
Take orally, preferably with food, to enhance absorption and reduce gastrointestinal upset. Shake the suspension well before each use. Use the provided measuring spoon or cup to ensure accurate dosing. Do not crush or chew tablets (if applicable).
Mechanism of Action
Cefuroxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death. It is bactericidal.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved approximately 2-3 hours after oral administration with food.
Excretion
Excreted unchanged in the urine, mainly by glomerular filtration and tubular secretion. Approximately 50% of an oral dose is excreted within 12 hours.
Half life
Approximately 1-1.5 hours in healthy adults.
Absorption
Well absorbed from the gastrointestinal tract and rapidly hydrolyzed by esterases to cefuroxime. Absorption is enhanced with food.
Metabolism
Not extensively metabolized in the liver; primarily hydrolyzed by esterases in the intestinal mucosa and blood to active cefuroxime.
Side Effects
Contraindications
- •Known hypersensitivity to cefuroxime, any other cephalosporin antibiotics, or any of the excipients in the formulation.
- •History of severe hypersensitivity reactions (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant administration with probenecid increases and prolongs cefuroxime plasma concentrations by reducing renal tubular secretion.
Oral Anticoagulants
Cefuroxime may affect gut flora, leading to lower vitamin K levels and potentially enhancing the anticoagulant effect. Monitor INR/PT.
Antacids/H2 Receptor Blockers/PPIs
These agents may reduce the bioavailability of cefuroxime axetil. It is recommended to take cefuroxime at least 1 hour before or 2 hours after antacids.
Storage
Store the dry powder below 30°C, protected from light and moisture. Keep out of reach of children. Reconstituted suspension must be stored in a refrigerator (2-8°C) and discarded after 7-10 days. Do not freeze.
Overdose
Symptoms of overdose typically include cerebral irritation which may lead to convulsions. Management is symptomatic and supportive. Hemodialysis can effectively reduce serum cefuroxime levels.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use in pregnancy only if clearly needed. Cefuroxime is excreted in small amounts into breast milk; generally considered compatible with breastfeeding, but caution is advised, and the infant should be monitored for potential adverse effects (e.g., diarrhea, candidiasis).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: Typically 24-36 months from manufacturing date. Reconstituted suspension: 7-10 days when stored in a refrigerator (2-8°C).
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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