Simox
Generic Name
Amoxicillin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| simox 125 mg suspension | ৳ 45.17 | N/A |
Description
Overview of the medicine
Simox 125 mg Suspension is an antibiotic medication containing Amoxicillin, used to treat a wide range of bacterial infections. It belongs to the penicillin class of antibiotics and works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Not typical dosage form for adults, usually higher strengths or different forms. If used, typically 250-500 mg every 8 hours.
Elderly
Dosage adjustment based on renal function.
Renal_impairment
Reduced dose and/or increased dosing interval based on creatinine clearance.
How to Take
Administer orally. Shake the suspension well before each use. Can be taken with or without food. Complete the full course of treatment as prescribed, even if symptoms improve.
Mechanism of Action
Amoxicillin is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Within 30-60 minutes
Excretion
Primarily excreted unchanged in the urine via renal tubular secretion and glomerular filtration.
Half life
Approximately 1-1.5 hours (in adults with normal renal function)
Absorption
Rapidly and well absorbed from the gastrointestinal tract, stable in gastric acid. Bioavailability is approximately 70-90%.
Metabolism
Limited metabolism; about 10-25% is metabolized to inactive penicilloic acid.
Side Effects
Contraindications
- Known hypersensitivity to penicillin or any component of Amoxicillin
- Previous history of severe allergic reaction to other beta-lactam antibiotics (e.g., cephalosporins)
Drug Interactions
Warfarin
May increase the anticoagulant effect (monitor INR).
Probenecid
Increases and prolongs Amoxicillin blood levels.
Allopurinol
Increased risk of rash.
Methotrexate
May increase methotrexate toxicity.
Oral Contraceptives
May reduce the effectiveness of oral contraceptives.
Storage
Store dry powder below 30°C (86°F), protected from moisture. Store reconstituted suspension in a refrigerator (2-8°C/36-46°F). Do not freeze.
Overdose
Symptoms may include nausea, vomiting, diarrhea, abdominal pain, and rarely convulsions. Treatment is generally supportive and symptomatic. Gastric lavage or activated charcoal may be considered if recent ingestion. Hemodialysis can remove Amoxicillin from circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe during pregnancy. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential side effects like diarrhea or rash.
Side Effects
Contraindications
- Known hypersensitivity to penicillin or any component of Amoxicillin
- Previous history of severe allergic reaction to other beta-lactam antibiotics (e.g., cephalosporins)
Drug Interactions
Warfarin
May increase the anticoagulant effect (monitor INR).
Probenecid
Increases and prolongs Amoxicillin blood levels.
Allopurinol
Increased risk of rash.
Methotrexate
May increase methotrexate toxicity.
Oral Contraceptives
May reduce the effectiveness of oral contraceptives.
Storage
Store dry powder below 30°C (86°F), protected from moisture. Store reconstituted suspension in a refrigerator (2-8°C/36-46°F). Do not freeze.
Overdose
Symptoms may include nausea, vomiting, diarrhea, abdominal pain, and rarely convulsions. Treatment is generally supportive and symptomatic. Gastric lavage or activated charcoal may be considered if recent ingestion. Hemodialysis can remove Amoxicillin from circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe during pregnancy. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential side effects like diarrhea or rash.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: 2-3 years. Reconstituted suspension: 7-14 days in refrigerator (check specific product for exact duration).
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic (patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Amoxicillin's efficacy and safety across various bacterial infections since its introduction.
Lab Monitoring
- No routine lab monitoring required for healthy individuals
- Renal function tests in patients with impaired renal function
- Liver function tests in patients with pre-existing hepatic impairment or prolonged therapy
Doctor Notes
- Emphasize importance of completing the full antibiotic course.
- Advise patients on proper reconstitution and storage of suspension.
- Caution about potential allergic reactions, especially in penicillin-allergic patients.
Patient Guidelines
- Complete the full course of antibiotics as prescribed.
- Do not save medication for future infections.
- Shake suspension well before each use.
- Discard any unused suspension after 14 days or as directed by pharmacist.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally not expected to impair ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Stay hydrated.
- Eat a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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