Simox
Generic Name
Amoxicillin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| simox 500 mg capsule | ৳ 6.02 | ৳ 60.20 |
Description
Overview of the medicine
Simox 500 mg Capsule is an antibiotic belonging to the penicillin group. It is used to treat a wide variety of bacterial infections.
Uses & Indications
Dosage
Adults
Standard: 250-500 mg every 8 hours, or 875 mg every 12 hours depending on the severity and type of infection. Severe infections may require higher doses.
Elderly
Dosage should be adjusted based on renal function. Generally, no specific dose adjustment required for age alone if renal function is normal.
Renal_impairment
Dosage reduction or increased dosing interval is necessary. For creatinine clearance 10-30 mL/min: 250-500 mg every 12 hours. For <10 mL/min: 250-500 mg every 24 hours.
How to Take
Take orally, with or without food. Swallow the capsule whole with water. Complete the full prescribed course of treatment even if symptoms improve.
Mechanism of Action
Amoxicillin works by inhibiting the synthesis of bacterial cell walls. It binds to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Clinical effects usually within 30 minutes to 1 hour.
Excretion
Primarily excreted unchanged in the urine (50-70%) by renal tubular secretion and glomerular filtration within 6 hours.
Half life
Approximately 1-1.5 hours in adults with normal renal function. Prolonged in renal impairment.
Absorption
Rapidly and well absorbed from the gastrointestinal tract. Peak plasma concentrations are achieved within 1-2 hours after oral administration. Food does not significantly affect absorption.
Metabolism
About 10-25% is metabolized to inactive penicilloic acid.
Side Effects
Contraindications
- Known hypersensitivity to penicillin or any other beta-lactam antibiotics (e.g., cephalosporins).
- History of severe allergic reaction to amoxicillin or other penicillins.
- Infectious mononucleosis (due to increased risk of rash).
Drug Interactions
Probenecid
Increases and prolongs amoxicillin blood levels by reducing renal tubular secretion.
Allopurinol
Concurrent use significantly increases the incidence of skin rash, especially in hyperuricemic patients.
Tetracyclines
Bacteriostatic antibiotics like tetracyclines may antagonize the bactericidal effect of penicillin.
Oral Contraceptives
Amoxicillin may reduce the efficacy of oral contraceptives; advise additional non-hormonal contraception.
Anticoagulants (e.g., Warfarin)
May prolong prothrombin time; careful monitoring is required.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include gastrointestinal symptoms (nausea, vomiting, diarrhea), fluid and electrolyte imbalance, and in severe cases, renal impairment or convulsions. Management is symptomatic and supportive, including hemodialysis if severe renal impairment occurs.
Pregnancy & Lactation
Pregnancy Category B. Amoxicillin is generally considered safe during pregnancy, but should only be used if clearly needed. It is excreted in small amounts in breast milk; usually not harmful to breastfed infants, but monitor for diarrhea or fungal infections in the infant. Consult your doctor before use.
Side Effects
Contraindications
- Known hypersensitivity to penicillin or any other beta-lactam antibiotics (e.g., cephalosporins).
- History of severe allergic reaction to amoxicillin or other penicillins.
- Infectious mononucleosis (due to increased risk of rash).
Drug Interactions
Probenecid
Increases and prolongs amoxicillin blood levels by reducing renal tubular secretion.
Allopurinol
Concurrent use significantly increases the incidence of skin rash, especially in hyperuricemic patients.
Tetracyclines
Bacteriostatic antibiotics like tetracyclines may antagonize the bactericidal effect of penicillin.
Oral Contraceptives
Amoxicillin may reduce the efficacy of oral contraceptives; advise additional non-hormonal contraception.
Anticoagulants (e.g., Warfarin)
May prolong prothrombin time; careful monitoring is required.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include gastrointestinal symptoms (nausea, vomiting, diarrhea), fluid and electrolyte imbalance, and in severe cases, renal impairment or convulsions. Management is symptomatic and supportive, including hemodialysis if severe renal impairment occurs.
Pregnancy & Lactation
Pregnancy Category B. Amoxicillin is generally considered safe during pregnancy, but should only be used if clearly needed. It is excreted in small amounts in breast milk; usually not harmful to breastfed infants, but monitor for diarrhea or fungal infections in the infant. Consult your doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on storage conditions.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Generic drug, patent expired
WHO Essential Medicine
YesClinical Trials
Amoxicillin is a well-established antibiotic; extensive clinical data supports its efficacy and safety. Newer trials focus on resistance patterns and combination therapies.
Lab Monitoring
- Renal function tests should be performed periodically during prolonged therapy, especially in patients with pre-existing renal impairment.
- Liver function tests may be monitored if liver dysfunction is suspected.
- Complete blood counts may be monitored during prolonged therapy.
Doctor Notes
- Always inquire about penicillin allergy history before prescribing.
- Advise patients on the importance of completing the full antibiotic course.
- Consider renal function in elderly patients or those with kidney impairment when dosing.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor; do not stop early, even if you feel better.
- Report any signs of an allergic reaction (e.g., rash, swelling, difficulty breathing) immediately.
- If diarrhea is severe or persistent, contact your doctor as it could be a sign of a serious condition.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Simox generally does not affect the ability to drive or operate machinery. However, if side effects like dizziness or confusion occur, avoid these activities.
Lifestyle Advice
- Drink plenty of fluids to stay hydrated, especially if you experience diarrhea.
- Avoid self-medication with antibiotics.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Simox Brand
Other medicines available under the same brand name
