sk-cef
Generic Name
Cefixime
Manufacturer
SK+F Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
sk cef 125 mg pediatric drop | ৳ 65.00 | N/A |
Description
Overview of the medicine
Cefixime is a broad-spectrum third-generation cephalosporin antibiotic used to treat a variety of bacterial infections, especially in pediatric patients. It is active against many Gram-positive and Gram-negative bacteria.
Uses & Indications
Dosage
Adults
Not typically for adults in this strength; standard adult dose is 400 mg once daily or 200 mg every 12 hours.
Elderly
Not typically for elderly in this strength; refer to adult dosage guidelines, adjust for renal function.
Renal_impairment
Dosage adjustment required for creatinine clearance < 60 mL/min. For CrCl 21-60 mL/min, 75% of standard dose. For CrCl < 20 mL/min, 50% of standard dose.
How to Take
For oral use. Reconstitute the powder with boiled and cooled water as per instructions. Shake well before each use. Can be taken with or without food.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Varies with infection type; generally, improvement seen within 24-48 hours.
Excretion
Primarily renal (about 50% unchanged in urine), some biliary excretion.
Half life
3 to 4 hours.
Absorption
Approximately 30-50% orally absorbed. Food slightly delays time to peak concentration.
Metabolism
Not extensively metabolized; primarily eliminated unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of anaphylactic reactions to penicillin
Drug Interactions
Warfarin
May enhance anticoagulant effect, monitor INR.
Carbamazepine
May increase carbamazepine levels, monitor levels.
Oral contraceptives
Efficacy may be reduced, advise additional contraception.
Storage
Store unreconstituted powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C) and discard after 7-14 days.
Overdose
Symptoms may include gastrointestinal distress (nausea, vomiting, diarrhea). Treatment is symptomatic and supportive. Gastric lavage may be considered. Hemodialysis or peritoneal dialysis is not effective in removing Cefixime.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of anaphylactic reactions to penicillin
Drug Interactions
Warfarin
May enhance anticoagulant effect, monitor INR.
Carbamazepine
May increase carbamazepine levels, monitor levels.
Oral contraceptives
Efficacy may be reduced, advise additional contraception.
Storage
Store unreconstituted powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C) and discard after 7-14 days.
Overdose
Symptoms may include gastrointestinal distress (nausea, vomiting, diarrhea). Treatment is symptomatic and supportive. Gastric lavage may be considered. Hemodialysis or peritoneal dialysis is not effective in removing Cefixime.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted powder: 2 years from manufacturing date. Reconstituted suspension: 7-14 days in refrigerator.
Availability
Pharmacies, Hospitals
Approval Status
Approved by drug regulatory authorities globally (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for its efficacy and safety in various bacterial infections, including pediatric populations. Ongoing post-marketing surveillance.
Lab Monitoring
- Periodic monitoring of renal function in patients with severe renal impairment.
- Liver function tests (rarely elevated).
- Complete blood count (rarely altered).
Doctor Notes
- Verify patient's allergies before prescribing, especially to penicillins or cephalosporins.
- Emphasize completion of the entire course to prevent resistance.
- Advise parents on proper reconstitution and storage of the suspension.
Patient Guidelines
- Complete the full course of antibiotic, even if symptoms improve.
- Do not share this medicine with others.
- Shake the suspension well before each use.
- Store the reconstituted suspension as directed.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime generally does not impair ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain good hydration.
- Ensure adequate rest.
- Follow a balanced diet.
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