SK-Cef
Generic Name
Cefuroxime
Manufacturer
Reputable Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sk cef 500 mg injection | ৳ 65.00 | N/A |
Description
Overview of the medicine
SK-Cef 500 mg Injection contains Cefuroxime, a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
Typically 750 mg to 1.5 g every 8 hours, administered intravenously or intramuscularly. For severe infections, up to 1.5 g every 6-8 hours.
Elderly
Dosage adjustment may be necessary in elderly patients with impaired renal function.
Renal_impairment
Dosage must be reduced based on creatinine clearance. For example, CrCl 10-20 mL/min: 750 mg once daily; CrCl <10 mL/min: 750 mg every 24-48 hours.
How to Take
Administered by slow intravenous injection over 3-5 minutes, intravenous infusion over 30-60 minutes, or deep intramuscular injection.
Mechanism of Action
Cefuroxime is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan polymers, leading to cell lysis and death.
Pharmacokinetics
Onset
Rapid (within minutes for IV)
Excretion
Primarily via the kidneys by glomerular filtration and tubular secretion.
Half life
Approximately 1.2 to 1.5 hours
Absorption
Administered intravenously or intramuscularly, resulting in rapid and complete absorption. Peak plasma concentrations are achieved shortly after administration.
Metabolism
Not extensively metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reaction to any other beta-lactam antibacterial agents (e.g., penicillins).
Drug Interactions
Probenecid
Decreases renal tubular secretion of cefuroxime, resulting in increased and prolonged plasma concentrations.
Loop Diuretics
May enhance nephrotoxic potential.
Aminoglycosides
Increased risk of nephrotoxicity.
Oral Anticoagulants
May increase anticoagulant effect.
Storage
Store below 25°C, protect from light and moisture. Reconstituted solution should be used immediately or within 24 hours if refrigerated.
Overdose
Symptoms of overdose include convulsions, encephalopathy. Management is symptomatic and supportive; hemodialysis may be effective in removing cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential adverse effects.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reaction to any other beta-lactam antibacterial agents (e.g., penicillins).
Drug Interactions
Probenecid
Decreases renal tubular secretion of cefuroxime, resulting in increased and prolonged plasma concentrations.
Loop Diuretics
May enhance nephrotoxic potential.
Aminoglycosides
Increased risk of nephrotoxicity.
Oral Anticoagulants
May increase anticoagulant effect.
Storage
Store below 25°C, protect from light and moisture. Reconstituted solution should be used immediately or within 24 hours if refrigerated.
Overdose
Symptoms of overdose include convulsions, encephalopathy. Management is symptomatic and supportive; hemodialysis may be effective in removing cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to packaging for exact expiry.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials demonstrating efficacy in various bacterial infections.
Lab Monitoring
- Renal function tests (creatinine, BUN) for prolonged therapy or in patients with renal impairment.
- Liver function tests periodically.
- Complete blood count (CBC) if long-term use.
Doctor Notes
- Always perform a thorough hypersensitivity history before administration.
- Adjust dose in renal impairment.
- Monitor for signs of superinfection, especially with prolonged use.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Report any severe diarrhea or allergic reactions immediately.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered, unless it's nearly time for the next dose. Do not double the dose.
Driving Precautions
Generally no impact on ability to drive or operate machinery, but if dizziness or other neurological effects occur, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Stay hydrated.
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