Administered by slow intravenous injection over 3-5 minutes, intravenous infusion over 30-60 minutes, or deep intramuscular injection.

Cefuroxime is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan polymers, leading to cell lysis and death.

• •Hypersensitivity to cefuroxime or any other cephalosporin antibiotics.
• •History of severe hypersensitivity reaction to any other beta-lactam antibacterial agents (e.g., penicillins).

Store below 25°C, protect from light and moisture. Reconstituted solution should be used immediately or within 24 hours if refrigerated.

Symptoms of overdose include convulsions, encephalopathy. Management is symptomatic and supportive; hemodialysis may be effective in removing cefuroxime from the body.

Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential adverse effects.