Adults

The usual adult dose of Cefixime is 400 mg once daily or 200 mg every 12 hours. For 500 mg capsule, dosage should be strictly as directed by physician based on infection type and severity.

Elderly

No dose adjustment is necessary for elderly patients unless there is severe renal impairment. Monitor renal function.

Renal_impairment

For creatinine clearance < 60 mL/min, dosage adjustment is required. Consult physician for specific dosage.

Onset

1-2 hours

Excretion

Primarily via urine (approximately 50% of absorbed dose) and bile (non-renal clearance).

Half life

3-4 hours

Absorption

Approximately 40-50% absorbed orally. Food may delay absorption but does not significantly affect the extent of absorption.

Metabolism

Limited hepatic metabolism; primarily excreted as unchanged drug.

Probenecid

May increase cefixime plasma concentrations by inhibiting renal excretion.

Carbamazepine

Elevated carbamazepine levels have been reported with concomitant cefixime use; monitor carbamazepine levels.

Oral Anticoagulants (e.g., Warfarin)

May increase prothrombin time and INR; monitor coagulation parameters closely.