Medicine Information

sk-cef

Name: sk-cef
Brand: sk-cef

Capsule250 mgAntibioticsATC: J01DD08

Generic Name

Cefixime

Manufacturer

SK+F Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
sk cef 250 mg capsule	৳ 8.00	৳ 48.00

Description

Overview of the medicine

SK-Cef 250 mg Capsule contains Cefixime, a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria and is effective against various Gram-positive and Gram-negative bacteria.

Uses & Indications

Uncomplicated Urinary Tract Infections (UTIs)

Otitis Media (middle ear infection)

Pharyngitis and Tonsillitis (throat infections)

Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis

Uncomplicated Gonorrhea

Dosage

Adults

The usual adult dose is 200 mg to 400 mg once daily or 200 mg twice daily. For SK-Cef 250 mg Capsule, typically 250 mg once daily or 250 mg twice daily, as directed by physician.

Elderly

No specific dose adjustment needed based solely on age, but renal function should be assessed, and dosage adjusted accordingly if renal impairment exists.

Renal_impairment

For creatinine clearance 21-60 mL/min: 75% of the standard dose. For creatinine clearance <20 mL/min: 50% of the standard dose.

How to Take

Take the capsule orally with a glass of water, with or without food, as directed by your doctor. It is important to complete the full course of treatment.

Mechanism of Action

Cefixime, a beta-lactam antibiotic, exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains essential for cell wall strength and integrity.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved 2-6 hours after administration.

Excretion

Primarily excreted unchanged in the urine (about 50%) and bile (about 10%) over 24 hours. Renal excretion is the main route.

Half life

Plasma half-life is typically 3-4 hours, potentially prolonged in renal impairment.

Absorption

Approximately 40-50% orally absorbed; food may delay absorption but does not significantly affect the extent.

Metabolism

Cefixime is not extensively metabolized in the body; about 10% may be metabolized by deacetylation.

Side Effects

Contraindications

Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.

Drug Interactions

Probenecid

May increase cefixime plasma levels by decreasing renal excretion.

Carbamazepine

Concomitant use may increase carbamazepine plasma concentrations.

Oral Anticoagulants (e.g., Warfarin)

May increase prothrombin time (INR) and risk of bleeding; close monitoring is advised.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment is largely symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in small amounts into breast milk; caution should be exercised when administered to a nursing woman.

Side Effects

Contraindications

Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.

Drug Interactions

Probenecid

May increase cefixime plasma levels by decreasing renal excretion.

Carbamazepine

Concomitant use may increase carbamazepine plasma concentrations.

Oral Anticoagulants (e.g., Warfarin)

May increase prothrombin time (INR) and risk of bleeding; close monitoring is advised.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 10 capsules (blister pack)3 x 10 capsules (box)

Shelf Life

Typically 24 to 36 months from the date of manufacture.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Cefixime has undergone extensive clinical trials for its efficacy and safety in treating various bacterial infections. Ongoing post-marketing surveillance continues to monitor its long-term effects and resistance patterns.

Lab Monitoring

Regular monitoring of renal function (creatinine clearance) in patients with pre-existing renal impairment or during prolonged high-dose therapy.
Monitoring of complete blood count (CBC) if hematological abnormalities are suspected.

Doctor Notes

Before prescribing, inquire about any history of allergic reactions to cephalosporins or penicillins.
Consider susceptibility testing, especially for recurrent or persistent infections.
Adjust dosage in patients with significant renal impairment.

Patient Guidelines

Complete the entire course of medication, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
Do not share this medication with others, as it may not be suitable for their condition.
Store the medication as directed and keep it out of reach of children.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Cefixime is generally not expected to impair the ability to drive or operate machinery. However, if side effects like dizziness or headache occur, patients should avoid such activities.