Sompraz
Generic Name
Esomeprazole
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sompraz 20 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Esomeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used to treat conditions such as gastroesophageal reflux disease (GERD), stomach ulcers, and other conditions involving excessive stomach acid.
Uses & Indications
Dosage
Adults
For GERD: 20-40 mg once daily for 4-8 weeks. For Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. For Zollinger-Ellison Syndrome: Initial dose 40 mg twice daily, adjusted as needed. For H. pylori eradication: 20 mg twice daily for 7-14 days in combination with antibiotics.
Elderly
No specific dosage adjustment is usually necessary for the elderly, but caution should be exercised in severe hepatic impairment.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Take one tablet whole, with a glass of water, at least 30-60 minutes before a meal, preferably in the morning. Do not chew or crush the tablet.
Mechanism of Action
Esomeprazole selectively inhibits the H+/K+-ATPase enzyme (the proton pump) in the parietal cells of the stomach. This irreversible inhibition blocks the final step in acid production, leading to a sustained reduction in gastric acid secretion.
Pharmacokinetics
Onset
Onset of acid suppression within 1 hour; maximal acid inhibition within 2-4 hours.
Excretion
Approximately 80% of the dose is excreted as metabolites in the urine, and the remainder (about 20%) in the feces.
Half life
Plasma elimination half-life is approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability is about 64% after a single dose, increasing to about 89% after repeated once-daily dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and to a lesser extent by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased absorption of digoxin due to increased gastric pH.
Warfarin
Increased INR and prothrombin time, increasing the risk of bleeding.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to inhibition of CYP2C19.
Methotrexate
Increased plasma concentrations and prolonged elimination of methotrexate, potentially leading to toxicity.
Atazanavir/Nelfinavir
Reduced plasma levels of these antiretrovirals, leading to loss of therapeutic effect.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Experience with esomeprazole overdose is limited. Symptoms may include drowsiness, tachycardia, headache, and abdominal pain. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is unknown if esomeprazole is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased absorption of digoxin due to increased gastric pH.
Warfarin
Increased INR and prothrombin time, increasing the risk of bleeding.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to inhibition of CYP2C19.
Methotrexate
Increased plasma concentrations and prolonged elimination of methotrexate, potentially leading to toxicity.
Atazanavir/Nelfinavir
Reduced plasma levels of these antiretrovirals, leading to loss of therapeutic effect.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Experience with esomeprazole overdose is limited. Symptoms may include drowsiness, tachycardia, headache, and abdominal pain. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is unknown if esomeprazole is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored correctly.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities worldwide including FDA and DGDA
Patent Status
Generic versions available, patent expired for original compound
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of esomeprazole in various acid-related disorders, including GERD, erosive esophagitis, and Zollinger-Ellison Syndrome. Studies have shown superior acid control compared to other PPIs in some cases.
Lab Monitoring
- Serum magnesium levels (especially with prolonged use or concomitant digoxin/diuretics)
- INR/prothrombin time (if co-administered with warfarin)
- Liver function tests (in patients with severe hepatic impairment)
Doctor Notes
- Advise patients on the importance of taking esomeprazole 30-60 minutes before a meal for optimal efficacy.
- Counsel patients on potential long-term risks associated with PPIs, such as hypomagnesemia and bone fractures, and discuss appropriate monitoring if prolonged therapy is anticipated.
- Remind patients not to stop PPI therapy abruptly due to potential acid rebound.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not crush, chew, or split the tablet; swallow it whole.
- Take 30-60 minutes before your first meal of the day.
- Do not stop taking the medicine abruptly without consulting your doctor.
- Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Esomeprazole may cause dizziness or visual disturbances in some patients. If you experience these side effects, avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty, acidic foods, caffeine, and alcohol.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating; wait at least 2-3 hours.
- Elevate the head of your bed while sleeping.
- Quit smoking as it can worsen acid reflux.
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