Sompraz
Generic Name
Esomeprazole 40 mg delayed-release capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sompraz 40 mg capsule | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Sompraz-40 mg capsule is a proton pump inhibitor used to treat conditions involving excessive stomach acid, such as GERD, peptic ulcers, and Zollinger-Ellison syndrome. It works by reducing the amount of acid produced in the stomach.
Uses & Indications
Dosage
Adults
For GERD, 20 mg or 40 mg once daily for 4 to 8 weeks. For Zollinger-Ellison Syndrome, initial dose 40 mg twice daily, adjusted as needed. For H. pylori eradication, 40 mg once daily with amoxicillin and clarithromycin for 10 days.
Elderly
No specific dose adjustment is needed in the elderly.
Renal_impairment
No dose adjustment is generally necessary for patients with renal impairment.
How to Take
Sompraz-40 mg capsule should be taken whole with water at least one hour before a meal. Do not chew or crush the capsule.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically and irreversibly blocks the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells. This inhibition prevents the final step of acid production, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted in urine (80%) and feces (20%) as metabolites.
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations achieved within 1-2 hours. Bioavailability is approximately 64% after a single 40 mg dose, increasing to 89% after repeated dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased absorption of digoxin due to increased gastric pH.
Diazepam
Reduced clearance of diazepam (CYP2C19 substrate).
Warfarin
Increased INR and prothrombin time have been reported, requiring monitoring.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel.
Methotrexate
Increased and prolonged serum levels of methotrexate and/or its metabolite.
Atazanavir, Nelfinavir
Significant reduction in plasma levels of these antiretrovirals.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include lethargy, drowsiness, blurred vision, tachycardia, nausea, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Excretion into breast milk is unknown, caution is advised.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased absorption of digoxin due to increased gastric pH.
Diazepam
Reduced clearance of diazepam (CYP2C19 substrate).
Warfarin
Increased INR and prothrombin time have been reported, requiring monitoring.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel.
Methotrexate
Increased and prolonged serum levels of methotrexate and/or its metabolite.
Atazanavir, Nelfinavir
Significant reduction in plasma levels of these antiretrovirals.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include lethargy, drowsiness, blurred vision, tachycardia, nausea, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Excretion into breast milk is unknown, caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generics available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated esomeprazole's efficacy and safety in various acid-related disorders, supporting its use in GERD, peptic ulcers, and H. pylori eradication.
Lab Monitoring
- Serum magnesium levels (especially with prolonged use or concomitant digoxin/diuretics)
- Liver function tests
- INR/PT (if on warfarin)
Doctor Notes
- Consider the lowest effective dose for the shortest possible duration.
- Evaluate underlying causes for dyspepsia before initiating PPI therapy.
- Monitor for hypomagnesemia in patients on long-term therapy, especially with diuretics.
Patient Guidelines
- Take the capsule whole; do not chew, crush, or open.
- Take it at least one hour before a meal.
- Inform your doctor if you experience severe diarrhea, unexplained weight loss, or difficulty swallowing.
- Long-term use may increase the risk of certain bone fractures and low magnesium levels.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
May cause dizziness or blurred vision in some individuals; caution is advised when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid trigger foods (e.g., spicy, fatty, acidic foods)
- Reduce alcohol and caffeine intake
- Avoid lying down immediately after meals
- Maintain a healthy weight
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