Sompraz
Generic Name
Esomeprazole 40 mg tablet
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sompraz 40 mg tablet | ৳ 9.50 | ৳ 95.00 |
Description
Overview of the medicine
Sompraz 40 mg Tablet contains Esomeprazole, a proton pump inhibitor that reduces the amount of acid produced in the stomach. It is used to treat conditions like acid reflux, heartburn, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD with Erosive Esophagitis: 20 mg or 40 mg once daily for 4 to 8 weeks. Maintenance: 20 mg once daily. Zollinger-Ellison Syndrome: Initial 40 mg twice daily, adjusted as needed.
Elderly
No dose adjustment generally required, but consider lower starting dose due to potential for reduced hepatic function.
Renal_impairment
No dose adjustment necessary for patients with renal impairment.
How to Take
Take the tablet whole with a glass of water, at least one hour before a meal. Do not crush or chew. If unable to swallow, dissolve in non-carbonated water and drink immediately.
Mechanism of Action
Esomeprazole selectively inhibits the gastric parietal cell H+/K+-ATPase (proton pump), thereby blocking the final step of acid secretion. This leads to a dose-dependent inhibition of both basal and stimulated gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Excreted primarily via the urine (approximately 80%) and feces (approximately 20%) as metabolites.
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached in 1-2 hours. Bioavailability is about 64% after a single 40 mg dose.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, mainly by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, other substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir (an antiretroviral drug).
Drug Interactions
Digoxin
Increased digoxin levels (monitor closely).
Warfarin
Increased INR/prothrombin time (monitor closely).
Tacrolimus
Increased tacrolimus levels (monitor concentrations).
Clopidogrel
Reduced antiplatelet effect of clopidogrel (avoid concomitant use).
Methotrexate
Increased methotrexate levels (monitor closely).
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, disorientation, tachycardia, and nausea. Management is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution advised during breastfeeding, consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, other substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir (an antiretroviral drug).
Drug Interactions
Digoxin
Increased digoxin levels (monitor closely).
Warfarin
Increased INR/prothrombin time (monitor closely).
Tacrolimus
Increased tacrolimus levels (monitor concentrations).
Clopidogrel
Reduced antiplatelet effect of clopidogrel (avoid concomitant use).
Methotrexate
Increased methotrexate levels (monitor closely).
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, disorientation, tachycardia, and nausea. Management is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution advised during breastfeeding, consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired for original molecule; generics available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Esomeprazole's efficacy and safety in various acid-related disorders. Ongoing studies continue to explore its long-term effects and new indications.
Lab Monitoring
- Monitor vitamin B12 levels during prolonged therapy (over 3 years) due to potential for malabsorption.
- Monitor serum magnesium levels periodically in patients on long-term treatment (≥3 months) or with concomitant drugs known to cause hypomagnesemia.
Doctor Notes
- Review the necessity of continued PPI therapy periodically, especially for long-term users.
- Consider the lowest effective dose for maintenance therapy.
- Be aware of potential drug interactions, particularly with clopidogrel and methotrexate.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Swallow the tablet whole; do not crush, chew, or split it.
- Take it at least one hour before a meal for best results.
- Do not stop taking the medicine suddenly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Sompraz is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Avoid trigger foods (spicy, fatty, acidic), alcohol, and caffeine. Maintain a healthy weight and avoid lying down immediately after eating.
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