Sonexa
Generic Name
sonexa-6-mg-tablet
Manufacturer
Specific manufacturer for Sonexa-6mg not universally available; usually local manufacturers.
Country
Varies by manufacturer and region
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sonexa 6 mg tablet | ৳ 13.00 | ৳ 130.00 |
Description
Overview of the medicine
Eszopiclone is a non-benzodiazepine hypnotic used for the treatment of insomnia. It helps patients fall asleep faster and stay asleep longer. The 6 mg strength is higher than typically recommended for most patients, as the maximum recommended dose is usually 3 mg.
Uses & Indications
Dosage
Adults
The recommended starting dose of Eszopiclone is 1 mg immediately before bedtime. The dose can be increased to 2 mg or 3 mg if clinically indicated. A 6 mg dose is generally not recommended due to increased side effects and risk of next-day impairment.
Elderly
The recommended starting dose for elderly patients is 1 mg immediately before bedtime. The dose should not exceed 2 mg due to increased sensitivity.
Renal_impairment
No dosage adjustment is necessary for patients with mild to moderate renal impairment. For severe renal impairment, use with caution, and a lower dose may be considered.
How to Take
Take orally, once daily, immediately before bedtime. Do not take with or immediately after a heavy, high-fat meal as this may delay the onset of action. Ensure at least 7-8 hours are available for sleep.
Mechanism of Action
Eszopiclone is a cyclopyrrolone that interacts with GABA-A receptor complexes, likely at an allosteric site distinct from the benzodiazepine binding site, leading to potentiation of GABAergic neurotransmission. This results in hypnotic and sedative effects.
Pharmacokinetics
Onset
Within 1 hour (hypnotic effects).
Excretion
Excreted primarily in the urine (approximately 56%) and feces (approximately 34%) as metabolites.
Half life
Approximately 5-6 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations achieved within approximately 1 hour.
Metabolism
Extensively metabolized by oxidation and demethylation via cytochrome P450 (CYP3A4 and CYP2E1) enzymes in the liver.
Side Effects
Contraindications
- •Known hypersensitivity to Eszopiclone or any inactive ingredient in the formulation.
- •Patients who have experienced complex sleep behaviors after taking Eszopiclone.
- •Severe hepatic impairment (use with caution).
Drug Interactions
CYP3A4 inducers (e.g., Rifampin, Carbamazepine)
May decrease Eszopiclone plasma concentrations, reducing its efficacy.
CYP3A4 inhibitors (e.g., Ketoconazole, Clarithromycin)
May increase Eszopiclone plasma concentrations, leading to enhanced sedative effects. Dosage adjustment may be required.
CNS depressants (e.g., Alcohol, Opioids, Benzodiazepines)
May cause additive CNS depressant effects, including increased sedation and respiratory depression. Avoid concomitant use or use with extreme caution.
Storage
Store at controlled room temperature (20-25°C), away from moisture and light. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, impaired coordination, flaccid muscles, and possible coma. Management involves general supportive measures, gastric lavage, and monitoring of vital signs. Flumazenil may be considered in severe cases but can precipitate withdrawal.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to potential sedation and withdrawal symptoms in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved by regulatory bodies (e.g., FDA for Eszopiclone)
Patent Status
Generic versions available, original patent expired
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Global Brand Names
International brand names for this medicine
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