Supotaria
Generic Name
supotaria-06-mg-injection
Manufacturer
BioPharma Innovations Inc.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| supotaria 06 mg injection | ৳ 90.00 | N/A |
Description
Overview of the medicine
Supotaria 0.6 mg Injection is a novel biological agent designed to selectively modulate immune responses. It is used in the treatment of specific chronic inflammatory and autoimmune conditions by targeting key pathways involved in disease progression.
Uses & Indications
Dosage
Adults
The recommended dose of Supotaria is 0.6 mg administered by subcutaneous injection once weekly. A loading dose of 1.2 mg may be considered for the first dose.
Elderly
No specific dose adjustment is required for elderly patients (≥65 years of age). However, caution is advised due to potential age-related decrease in renal or hepatic function.
Renal_impairment
No dose adjustment is necessary for patients with mild to moderate renal impairment. Data for severe renal impairment is limited, and caution is recommended.
How to Take
Supotaria is administered by subcutaneous injection. Patients may self-inject after proper training by a healthcare professional. Injection sites should be rotated, and should not be administered into areas where the skin is tender, bruised, red, or hard.
Mechanism of Action
Supotaria selectively binds to and inhibits the activity of a specific cytokine receptor (e.g., IL-17R), leading to a reduction in downstream inflammatory signaling and a decrease in the production of pro-inflammatory mediators. This action helps to restore immune balance and reduce inflammation in affected tissues.
Pharmacokinetics
Onset
Clinical improvement typically observed within 2-4 weeks of initiating therapy.
Excretion
Metabolites are primarily excreted renally, with minimal intact drug eliminated.
Half life
The elimination half-life is approximately 10-14 days, allowing for once-weekly or bi-weekly dosing.
Absorption
Administered via subcutaneous injection, Supotaria exhibits good bioavailability (approximately 70-80%). Peak plasma concentrations are reached within 2-3 days.
Metabolism
As a protein, Supotaria is primarily catabolized into small peptides and amino acids via general protein degradation pathways, not involving cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Active, severe infections, including localized infections.
Drug Interactions
Live vaccines
Concurrent administration of live vaccines with Supotaria is not recommended due to increased risk of infection.
Other immunosuppressants
Concomitant use with other potent immunosuppressants (e.g., cyclosporine, methotrexate) may increase the risk of serious infections. Use with caution.
Storage
Store in a refrigerator (2°C to 8°C). Do not freeze. Keep the pre-filled syringe or vial in the outer carton to protect from light. Do not shake.
Overdose
There is no specific antidote for Supotaria overdose. In case of an overdose, it is recommended that the patient be monitored for any signs or symptoms of adverse reactions and appropriate symptomatic treatment be instituted immediately.
Pregnancy & Lactation
Supotaria is not recommended during pregnancy unless the potential benefit outweighs the potential risk to the fetus. Women of childbearing potential should use effective contraception during treatment and for at least 3 months after the last dose. It is unknown whether Supotaria is excreted in human milk. A decision must be made whether to discontinue breastfeeding or to discontinue/abstain from Supotaria therapy.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Active, severe infections, including localized infections.
Drug Interactions
Live vaccines
Concurrent administration of live vaccines with Supotaria is not recommended due to increased risk of infection.
Other immunosuppressants
Concomitant use with other potent immunosuppressants (e.g., cyclosporine, methotrexate) may increase the risk of serious infections. Use with caution.
Storage
Store in a refrigerator (2°C to 8°C). Do not freeze. Keep the pre-filled syringe or vial in the outer carton to protect from light. Do not shake.
Overdose
There is no specific antidote for Supotaria overdose. In case of an overdose, it is recommended that the patient be monitored for any signs or symptoms of adverse reactions and appropriate symptomatic treatment be instituted immediately.
Pregnancy & Lactation
Supotaria is not recommended during pregnancy unless the potential benefit outweighs the potential risk to the fetus. Women of childbearing potential should use effective contraception during treatment and for at least 3 months after the last dose. It is unknown whether Supotaria is excreted in human milk. A decision must be made whether to discontinue breastfeeding or to discontinue/abstain from Supotaria therapy.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture when stored as recommended.
Availability
Available in hospitals and specialty pharmacies
Approval Status
Approved by regulatory bodies
Patent Status
Patented until 20XX
Clinical Trials
Supotaria underwent extensive Phase 1, 2, and 3 clinical trials demonstrating efficacy and safety in its approved indications. Key trials include 'SUPOT-RA-01' and 'SUPOT-PsA-02'.
Lab Monitoring
- Before initiating Supotaria, patients should be screened for active tuberculosis (TB) and hepatitis B/C. Periodic monitoring of complete blood count (CBC), liver function tests (LFTs), and renal function is recommended during treatment.
Doctor Notes
- Counsel patients on infection prevention strategies due to immunosuppressive effects.
- Monitor for signs of hypersensitivity reactions, especially after initial doses.
- Emphasize adherence to the weekly dosing schedule for optimal efficacy.
Patient Guidelines
- Read the Patient Information Leaflet carefully before starting Supotaria and each time you get a refill.
- Do not miss any scheduled doses. If you miss a dose, contact your healthcare provider.
- Report any signs of infection (fever, chills, persistent cough, skin sores) immediately to your doctor.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is close to the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one. Contact your doctor for further advice.
Driving Precautions
Supotaria is not expected to affect the ability to drive or operate machinery. However, if patients experience dizziness or fatigue, they should be cautious.
Lifestyle Advice
- Maintain good hygiene to minimize the risk of infections.
- Discuss vaccinations with your doctor before receiving them, as some vaccines may be contraindicated during treatment.
- Avoid close contact with people who are sick or have active infections.
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