Supotaria
Generic Name
Tiotropium Bromide
Manufacturer
Generic Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| supotaria 25 mcg respirator solution | ৳ 30.00 | N/A |
Description
Overview of the medicine
Supotaria 25 mcg Respirator Solution contains Tiotropium Bromide, a long-acting anticholinergic bronchodilator used for the maintenance treatment of chronic obstructive pulmonary disease (COPD).
Uses & Indications
Dosage
Adults
One inhalation (25 mcg) once daily, administered at the same time each day using the specified respirator device.
Elderly
No dosage adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with mild to moderate renal impairment. For severe renal impairment, monitor closely.
How to Take
For oral inhalation only. Do not swallow. Administer once daily using the specific inhaler device. Ensure proper inhalation technique as instructed by a healthcare professional.
Mechanism of Action
Tiotropium is a long-acting, competitive, and reversible antagonist of muscarinic cholinergic receptors (M1, M2, and M3) located in the airways. It inhibits acetylcholine's bronchoconstrictive effects, leading to bronchodilation. It preferentially binds to M1 and M3 receptors, which mediate bronchoconstriction.
Pharmacokinetics
Onset
Bronchodilation begins within 30 minutes of inhalation.
Excretion
Primarily excreted unchanged in urine (about 14% of the dose) and via the fecal route (about 70% of the dose).
Half life
Effective half-life is 25-30 hours, with a terminal half-life of 5-6 days after repeated inhalation in COPD patients.
Absorption
Systemic absorption is low following inhalation, with an absolute bioavailability of 19.5%. Peak plasma concentrations are reached within 5-7 minutes.
Metabolism
Undergoes minimal metabolism via non-enzymatic ester hydrolysis to an inactive alcohol and acid derivative.
Side Effects
Contraindications
- Hypersensitivity to Tiotropium, Atropine, or its derivatives (e.g., Ipratropium, Oxitropium), or to any component of the product.
- Not indicated for the initial treatment of acute episodes of bronchospasm (i.e., rescue therapy).
Drug Interactions
Other anticholinergics
Concomitant administration of other anticholinergic drugs may potentiate adverse effects. Avoid co-administration.
Beta-agonists and corticosteroids
No clinically significant pharmacokinetic interactions have been found when Tiotropium is co-administered with other commonly used COPD medications like sympathomimetic bronchodilators, methylxanthines, and oral or inhaled steroids.
Storage
Store at controlled room temperature (20°C to 25°C). Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose symptoms include anticholinergic effects like dry mouth, blurred vision, and constipation. Treatment is symptomatic and supportive. Close medical supervision is recommended.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Tiotropium is excreted in human milk. Exercise caution when administering to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Tiotropium, Atropine, or its derivatives (e.g., Ipratropium, Oxitropium), or to any component of the product.
- Not indicated for the initial treatment of acute episodes of bronchospasm (i.e., rescue therapy).
Drug Interactions
Other anticholinergics
Concomitant administration of other anticholinergic drugs may potentiate adverse effects. Avoid co-administration.
Beta-agonists and corticosteroids
No clinically significant pharmacokinetic interactions have been found when Tiotropium is co-administered with other commonly used COPD medications like sympathomimetic bronchodilators, methylxanthines, and oral or inhaled steroids.
Storage
Store at controlled room temperature (20°C to 25°C). Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose symptoms include anticholinergic effects like dry mouth, blurred vision, and constipation. Treatment is symptomatic and supportive. Close medical supervision is recommended.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Tiotropium is excreted in human milk. Exercise caution when administering to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Patent expired for generic versions
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials (e.g., UPLIFT, TIOSPIR) have demonstrated the efficacy and safety of Tiotropium in improving lung function, reducing COPD exacerbations, and improving quality of life in COPD patients.
Lab Monitoring
- Routine lab monitoring is generally not required.
- Monitor for signs of glaucoma or urinary retention in susceptible patients.
Doctor Notes
- Emphasize proper inhalation technique to ensure optimal drug delivery.
- Patients should be educated that this is a maintenance therapy, not for acute relief.
- Monitor for anticholinergic side effects, especially in elderly patients.
Patient Guidelines
- Use only as directed by your doctor.
- Do not use for sudden breathing problems; this medicine is for maintenance.
- Rinse your mouth after each use to reduce the risk of oral thrush.
- Follow the inhaler's instructions for proper use.
Missed Dose Advice
If a dose is missed, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not take two doses at once.
Driving Precautions
Tiotropium has no or negligible influence on the ability to drive and use machines. However, if side effects like dizziness or blurred vision occur, avoid driving or operating machinery.
Lifestyle Advice
- Avoid smoking to improve respiratory health.
- Engage in regular physical activity as advised by your doctor.
- Maintain a healthy diet.
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