Telfex
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| telfex 120 mg tablet | ৳ 8.00 | ৳ 80.00 |
| telfex 180 mg tablet | ৳ 10.00 | ৳ 100.00 |
| telfex 30 mg suspension | ৳ 50.00 | N/A |
Description
Overview of the medicine
Telfex (Fexofenadine) is a non-sedating antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy watery eyes, and itchy throat, as well as symptoms of chronic idiopathic urticaria like itching and hives.
Uses & Indications
Dosage
Adults
Seasonal allergic rhinitis: 60 mg twice daily or 180 mg once daily. Chronic idiopathic urticaria: 180 mg once daily.
Elderly
No dosage adjustment generally required, but caution with renal impairment.
Renal_impairment
For severe renal impairment (CrCl <10 mL/min), initial dose of 60 mg once daily is recommended.
How to Take
Oral administration. Can be taken with or without food. Avoid taking with fruit juice (grapefruit, orange, apple) as it may reduce absorption.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It competitively binds to H1 receptors, preventing histamine from binding and exerting its effects, thereby reducing allergy symptoms without significantly crossing the blood-brain barrier, which minimizes sedation.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted unchanged in bile (approximately 80%) and urine (approximately 11%).
Half life
Approximately 14 hours
Absorption
Rapidly absorbed after oral administration; Tmax is approximately 1-3 hours.
Metabolism
Minimally metabolized (less than 5%) in the liver.
Side Effects
Contraindications
- Known hypersensitivity to fexofenadine or any component of the formulation.
Drug Interactions
Erythromycin or Ketoconazole
May increase fexofenadine plasma concentrations, though clinical significance is usually minimal.
Antacids (containing aluminum and magnesium)
May reduce fexofenadine absorption. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose management: Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Management is symptomatic and supportive. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, caution advised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to fexofenadine or any component of the formulation.
Drug Interactions
Erythromycin or Ketoconazole
May increase fexofenadine plasma concentrations, though clinical significance is usually minimal.
Antacids (containing aluminum and magnesium)
May reduce fexofenadine absorption. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose management: Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Management is symptomatic and supportive. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, caution advised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, drugstores
Approval Status
Approved by health authorities worldwide (e.g., FDA, DGDA)
Patent Status
Generic available (patent expired)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established fexofenadine's efficacy and safety in seasonal allergic rhinitis and chronic idiopathic urticaria, demonstrating significant symptom relief and a favorable side effect profile compared to placebo.
Lab Monitoring
- No specific routine lab monitoring is generally required.
Doctor Notes
- Advise patients to avoid taking fexofenadine with fruit juices.
- Reassure patients about its non-sedating profile compared to older antihistamines.
- Consider renal dose adjustment in severe renal impairment.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking, including herbal supplements and OTC drugs.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Although Telfex is a non-sedating antihistamine, individual responses may vary. If you experience drowsiness or dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid known allergens to reduce symptoms.
- Stay hydrated.
- Avoid excessive alcohol consumption as it may worsen drowsiness.
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Global Brand Names
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